Journal article
The lowest effective dose of tissue plasminogen activator for fibrinolysis of postvitrectomy fibrin
Retina (Philadelphia, Pa.), Vol.12(3 Suppl), pp.S75-S79
1992
DOI: 10.1097/00006982-199212031-00016
PMID: 1455089
Abstract
Tissue plasminogen activator (tPA) has been shown to be effective at a dose of 25 micrograms in the treatment of severe postvitrectomy fibrin. However, a recent report based on an animal model indicates that retinal toxicity may occur at doses as low as 25 micrograms. This study uses a low dose (1.5 micrograms to 3 micrograms) of tPA for 34 injections in 26 eyes, and determines the lowest effective dose to be between 1.5 and 3 micrograms. Complete fibrinolysis was achieved in all 28 eyes in which 3 micrograms of tPA was administered within 10 days of vitrectomy, whereas partial fibrinolysis was achieved in eyes treated with 3 micrograms of tPA 27 days and 82 days after vitrectomy. Complete fibrinolysis occurred in only 1 of 4 eyes that receive 1.5 micrograms of tPA. A dose of 3 micrograms of tPA is recommended for treatment of severe fibrin after vitrectomy, as it has a wider margin of safety than do higher doses.
Details
- Title: Subtitle
- The lowest effective dose of tissue plasminogen activator for fibrinolysis of postvitrectomy fibrin
- Creators
- H Culver Boldt - Department of Ophthalmology, Medical College of Wisconsin, MilwaukeeGary W AbramsTimothy G MurrayDennis P HanWilliam F Mieler
- Resource Type
- Journal article
- Publication Details
- Retina (Philadelphia, Pa.), Vol.12(3 Suppl), pp.S75-S79
- DOI
- 10.1097/00006982-199212031-00016
- PMID
- 1455089
- NLM abbreviation
- Retina
- ISSN
- 0275-004X
- eISSN
- 1539-2864
- Grant note
- EY01931-15 / NEI NIH HHS
- Language
- English
- Date published
- 1992
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984083852902771
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