Journal article
The lutropin/choriogonadotropin receptor, a 2002 perspective
Endocrine reviews, Vol.23(2), pp.141-174
2002
DOI: 10.1210/edrv.23.2.0462
PMID: 11943741
Abstract
Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in the functions of the LHR during pregnancy have catastrophic consequences. As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor.
Details
- Title: Subtitle
- The lutropin/choriogonadotropin receptor, a 2002 perspective
- Creators
- Mario ASCOLI - Department of Pharmacology, The University of Iowa, Iowa City, Iowa 52242-1109, United StatesFrancesca FANELLI - Dipartimento di Chimica, Universitá di Modena e Reggio Emilia, Via Campi 183, 41100 Modena, ItalyDeborah L SEGALOFF - Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242-1109, United States
- Resource Type
- Journal article
- Publication Details
- Endocrine reviews, Vol.23(2), pp.141-174
- Publisher
- Endocrine Society
- DOI
- 10.1210/edrv.23.2.0462
- PMID
- 11943741
- ISSN
- 0163-769X
- eISSN
- 1945-7189
- Language
- English
- Date published
- 2002
- Academic Unit
- Molecular Physiology and Biophysics; Obstetrics and Gynecology; Neuroscience and Pharmacology
- Record Identifier
- 9984083811402771
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