The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS

J Michael Wells; Dongqi Xing; Liliana Viera; Robert M Burkes; Yixin Wu; Surya P Bhatt; Mark T Dransfield; David J Couper; Wanda O'Neal; Eric A Hoffman; Amit Gaggar; Igor Barjaktarevic; Jeffrey L Curtis; Wassim W Labaki; Mei Lan K Han; Christine M Freeman; Nirupama Putcha; Thomas Schlange; J Edwin Blalock; SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) Investigators

doi:10.1186/s12931-019-1230-8

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The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS

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The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS

J Michael Wells, Dongqi Xing, Liliana Viera, Robert M Burkes, Yixin Wu, Surya P Bhatt, Mark T Dransfield, David J Couper, Wanda O'Neal, Eric A Hoffman, …

Respiratory research, Vol.20(1), pp.254-254

11/12/2019

DOI: 10.1186/s12931-019-1230-8

PMCID: PMC6852714

PMID: 31718676

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Abstract

Pulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix components, or matrikines, and COPD pathogenesis. We studied the relationships between the matrikine acetyl-proline-glycine-proline (AcPGP) in sputum and plasma and clinical features of COPD. Sputum and plasma samples were obtained from COPD participants in the SPIROMICS cohort at enrollment. AcPGP was isolated using solid phase extraction and measured by mass spectrometry. Demographics, spirometry, quality of life questionnaires, and quantitative computed tomography (CT) imaging with parametric response mapping (PRM) were obtained at baseline. Severe COPD exacerbations were recorded at 1-year of prospective follow-up. We used linear and logistic regression models to measure associations between AcPGP and features of COPD, and Kaplan-Meier analyses to measure time-to-first severe exacerbation. The 182 COPD participants in the analysis were 66 ± 8 years old, 62% male, 84% White race, and 39% were current smokers. AcPGP concentrations were 0.61 ± 1.89 ng/mL (mean ± SD) in sputum and 0.60 ± 1.13 ng/mL in plasma. In adjusted linear regression models, sputum AcPGP was associated with FEV /FVC, spirometric GOLD stage, PRM-small airways disease, and PRM-emphysema. Sputum AcPGP also correlated with severe AECOPD, and elevated sputum AcPGP was associated with shorter time-to-first severe COPD exacerbation. In contrast, plasma AcPGP was not associated with symptoms, pulmonary function, or severe exacerbation risk. In COPD, sputum but not plasma AcPGP concentrations are associated with the severity of airflow limitation, small airways disease, emphysema, and risk for severe AECOPD at 1-year of follow-up. ClinicalTrials.gov: NCT01969344 (SPIROMICS).

Aged

Biomarkers - blood

Cohort Studies

Female

Glycine - blood

Humans

Male

Middle Aged

Proline - blood

Prospective Studies

Pulmonary Disease, Chronic Obstructive - blood

Pulmonary Disease, Chronic Obstructive - diagnostic imaging

Spirometry - methods

Sputum - chemistry

Sputum - metabolism

Details

Title: Subtitle: The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS
Creators: J Michael Wells - Birmingham VA Medical Center
Dongqi Xing - University of Alabama at Birmingham
Liliana Viera - University of Alabama at Birmingham
Robert M Burkes - University of North Carolina at Chapel Hill
Yixin Wu - University of Alabama at Birmingham
Surya P Bhatt - University of Alabama at Birmingham
Mark T Dransfield - University of Alabama at Birmingham
David J Couper - University of North Carolina at Chapel Hill
Wanda O'Neal - University of North Carolina at Chapel Hill
Eric A Hoffman - University of Iowa
Amit Gaggar - Birmingham VA Medical Center
Igor Barjaktarevic - University of California, Los Angeles
Jeffrey L Curtis - University of Michigan–Ann Arbor
Wassim W Labaki - University of Michigan
Mei Lan K Han - University of Michigan
Christine M Freeman - University of Michigan–Ann Arbor
Nirupama Putcha - Johns Hopkins University
Thomas Schlange - Bayer
J Edwin Blalock - University of Alabama at Birmingham
SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) Investigators
Resource Type: Journal article
Publication Details: Respiratory research, Vol.20(1), pp.254-254
DOI: 10.1186/s12931-019-1230-8
PMID: 31718676
PMCID: PMC6852714
NLM abbreviation: Respir Res
ISSN: 1465-993X
eISSN: 1465-993X
Grant note: R01HL114439, R01HL126596,and R35HL135710 / National Heart, Lung, and Blood Institute (US) P30 ES005605 / NIEHS NIH HHS K24 HL140108 / NHLBI NIH HHS U24 HL141762 / NHLBI NIH HHS U01 HL137880 / NHLBI NIH HHS I01 CX000911 / CSRD VA K24 HL137013 / NHLBI NIH HHS I01BX001756 / U.S. Department of Veterans Affairs HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C, HHSN268200900019C, HHSN268200900020C, U01 HL137880 / National Heart, Lung, and Blood Institute (US) K08 HL123940 / NHLBI NIH HHS I01 CX001553 / CSRD VA S10 OD018526 / NIH HHS P30 DK054759 / NIDDK NIH HHS R01 HL102371 / NHLBI NIH HHS
Language: English
Date published: 11/12/2019
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984318807702771

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