The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

Shuang Rong; Liangliang Wang; Zhao Peng; Yuxiao Liao; Dan Li; Xuefeng Yang; Andreas K Nuessler; Liegang Liu; Wei Bao; Wei Yang

doi:10.1002/jcsm.12536

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The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

Journal article

Open access

Peer reviewed

The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

Shuang Rong, Liangliang Wang, Zhao Peng, Yuxiao Liao, Dan Li, Xuefeng Yang, Andreas K Nuessler, Liegang Liu, Wei Bao and Wei Yang

Journal of cachexia, sarcopenia and muscle, Vol.11(2), pp.348-365

04/2020

DOI: 10.1002/jcsm.12536

PMCID: PMC7113536

PMID: 31989804

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Abstract

The age-related loss of muscle mass and muscle function known as sarcopenia is a primary contributor to the problems faced by the old people. Sarcopenia has been a major public health problem with high prevalence in many countries. The related underlying molecular mechanisms of sarcopenia are not completely understood. This review is focused on the potential mechanisms and current research strategies for sarcopenia with the aim of facilitating the recognition and treatment of age-related sarcopenia. Previous studies suggested that protein synthesis and degradation, autophagy, impaired satellite cell activation, mitochondria dysfunction, and other factors associated with muscle weakness and muscle degeneration may be potential molecular pathophysiology of sarcopenia. Importantly, we also prospectively highlight that exosomes (small vesicles) as carriers can regulate muscle regeneration and protein synthesis according to recent researches. Dietary strategies and exercise represent the interventions that can also alleviate the progression of sarcopenia. At last, building on recent studies pointing to exosomes with the roles in increasing muscle regeneration, mediating the beneficial effects of exercise, and serving as messengers of intercellular communication and as carriers for research strategies of many diseases, we propose that exosomes could be a potential research direction or strategies of sarcopenia in the future.

Aging

Research direction

Sarcopenia

Exosomes

Dietary strategies

Muscle loss

Details

Title: Subtitle: The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?
Creators: Shuang Rong - Department of Nutrition and Food Hygiene, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, China
Liangliang Wang - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Zhao Peng - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Yuxiao Liao - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Dan Li - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Xuefeng Yang - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Andreas K Nuessler - Department of Traumatology, BG Trauma Center, University of Tübingen, Tübingen, Germany
Liegang Liu - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Wei Bao - Department of Epidemology, College of Public Health, University of Iowa, IA, USA
Wei Yang - Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Resource Type: Journal article
Publication Details: Journal of cachexia, sarcopenia and muscle, Vol.11(2), pp.348-365
DOI: 10.1002/jcsm.12536
PMID: 31989804
PMCID: PMC7113536
NLM abbreviation: J Cachexia Sarcopenia Muscle
ISSN: 2190-5991
eISSN: 2190-6009
Publisher: Germany
Grant note: AF2017004 / An Qi Nutrition Fund NSFC81502811 / National Natural Science Foundation of China
Language: English
Date published: 04/2020
Academic Unit: Epidemiology
Record Identifier: 9984066341502771

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