The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity

Undral Munkhsaikhan; Youngin Kwon; Amal M. Sahyoun; Karima Ait‐Aissa; Adam Kassan; Modar Kassan

doi:10.1002/oby.23389

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The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity

Journal article

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The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity

Undral Munkhsaikhan, Youngin Kwon, Amal M. Sahyoun, Karima Ait‐Aissa, Adam Kassan and Modar Kassan

Obesity (Silver Spring, Md.), Vol.30(4), pp.893-901

04/2022

DOI: 10.1002/oby.23389

PMCID: PMC8957593

PMID: 35253407

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https://www.ncbi.nlm.nih.gov/pmc/articles/8957593View

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Abstract

Objective In this study, the effect of lomitapide, a microsomal triglyceride transfer protein inhibitor, on the cardiovascular function in obesity was investigated. Methods Eight‐week‐old C57BL/6 mice were fed with high‐fat diet for 12 weeks in the presence and absence of lomitapide. Lomitapide was administered by gavage (1 mg/kg/d) during the last 2 weeks of high‐fat feeding. Body weight, blood glucose, body composition, and lipid profile were determined. Vascular function and endothelial function markers were studied in the aorta and mesenteric resistance arteries. Results Lomitapide treatment reduced body weight in mice with obesity. Blood glucose, percentage of fat mass, total cholesterol, and low‐density lipoprotein levels were significantly reduced, and the percentage of lean mass was significantly increased after lomitapide treatment. The vascular response to sodium nitroprusside in the aorta and mesenteric arteries was similar among groups. However, the vascular response to acetylcholine was improved in the treated group. This was associated with decreased levels of vascular endoplasmic reticulum stress, inflammation, and oxidative stress. Conclusions Treatment with lomitapide attenuated the increase in body weight in mice with obesity and restored the lipid profile and vascular function. These effects were accompanied by a decrease in inflammation and oxidative stress.

Details

Title: Subtitle: The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity
Creators: Undral Munkhsaikhan - University of Tennessee Health Science Center
Youngin Kwon - University of Tennessee Health Science Center
Amal M. Sahyoun - McGill University
Karima Ait‐Aissa - Roy J. and Lucille A. Carver College of Medicine
Adam Kassan - West Coast University
Modar Kassan - University of Tennessee Health Science Center
Resource Type: Journal article
Publication Details: Obesity (Silver Spring, Md.), Vol.30(4), pp.893-901
DOI: 10.1002/oby.23389
PMID: 35253407
PMCID: PMC8957593
NLM abbreviation: Obesity (Silver Spring)
ISSN: 1930-7381
eISSN: 1930-739X
Number of pages: 9
Grant note: NIH (7R01HL150360‐02)
Language: English
Date published: 04/2022
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984359867602771

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