Journal article
The midlatency auditory evoked potential P50 is abnormal in Huntington's disease
Journal of the neurological sciences, Vol.212(1), pp.1-5
2003
DOI: 10.1016/S0022-510X(03)00082-0
PMID: 12809992
Abstract
The P50 (or P1) potential is a midlatency auditory evoked response, believed to be partially generated by the cholinergic pedunculopontine nucleus (PPN) neurons that give rise to the ascending reticular activating system (RAS). We compared the P50 potential in 11 Huntington's disease (HD) patients and 13 normal controls using a paired click stimulus paradigm. HD patients exhibited a P50 potential with reduced amplitude and increased latency to the first stimulus of the pair (first P50 potential), suggesting impaired ascending reticular activating system function, which may contribute to sleep disorders seen in HD. Sensory gating, measured as the percent ratio of the second P50 potential amplitude to the first P50 potential amplitude, was reduced at 250 and 500 ms interstimulus intervals (ISI), which may be related to disordered attention and anxiety in HD.
Details
- Title: Subtitle
- The midlatency auditory evoked potential P50 is abnormal in Huntington's disease
- Creators
- Ergun Y Uc - Department of Neurology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, USARobert D Skinner - Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, Little Rock, AR, USARobert L Rodnitzky - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USAEdgar Garcia-Rill - Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
- Resource Type
- Journal article
- Publication Details
- Journal of the neurological sciences, Vol.212(1), pp.1-5
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0022-510X(03)00082-0
- PMID
- 12809992
- ISSN
- 0022-510X
- eISSN
- 1878-5883
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: NS20246, RR14288
- Language
- English
- Date published
- 2003
- Academic Unit
- Neurology
- Record Identifier
- 9984020867602771
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