The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?

Bernd Fritzsch; Kirk W Beisel; Laura A Hansen

doi:10.1002/bies.20502

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The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?

Journal article

Peer reviewed

The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?

Bernd Fritzsch, Kirk W Beisel and Laura A Hansen

BioEssays, Vol.28(12), pp.1181-1193

12/2006

DOI: 10.1002/bies.20502

PMCID: PMC3901523

PMID: 17120192

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https://www.ncbi.nlm.nih.gov/pmc/articles/3901523View

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Abstract

The inner ear of mammals uses neurosensory cells derived from the embryonic ear for mechanoelectric transduction of vestibular and auditory stimuli (the hair cells) and conducts this information to the brain via sensory neurons. As with most other neurons of mammals, lost hair cells and sensory neurons are not spontaneously replaced and result instead in age-dependent progressive hearing loss. We review the molecular basis of neurosensory development in the mouse ear to provide a blueprint for possible enhancement of therapeutically useful transformation of stem cells into lost neurosensory cells. We identify several readily available adult sources of stem cells that express, like the ectoderm-derived ear, genes known to be essential for ear development. Use of these stem cells combined with molecular insights into neurosensory cell specification and proliferation regulation of the ear, might allow for neurosensory regeneration of mammalian ears in the near future.

Ectoderm - cytology

Hair Cells, Auditory - cytology

Neurons, Afferent - cytology

Animals

Ear - physiology

Humans

Ear - embryology

Stem Cells - cytology

Nerve Regeneration

Details

Title: Subtitle: The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?
Creators: Bernd Fritzsch - Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA. Fritzsch@Creighton.edu
Kirk W Beisel
Laura A Hansen
Resource Type: Journal article
Publication Details: BioEssays, Vol.28(12), pp.1181-1193
DOI: 10.1002/bies.20502
PMID: 17120192
PMCID: PMC3901523
NLM abbreviation: Bioessays
ISSN: 0265-9247
eISSN: 1521-1878
Publisher: United States
Grant note: R01 DC005009 / NIDCD NIH HHS\nR01 DC005590 / NIDCD NIH HHS\nDC005009 / NIDCD NIH HHS\n1P20RR018788-01 / NCRR NIH HHS\nP20 RR018788 / NCRR NIH HHS\nC06 RR017417 / NCRR NIH HHS\nR01 DC005590-05 / NIDCD NIH HHS
Language: English
Date published: 12/2006
Academic Unit: Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
Record Identifier: 9984070129502771

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