Journal article
The molecular virology of coronaviruses
The Journal of biological chemistry, Vol.295(37), pp.12910-12934
09/11/2020
DOI: 10.1074/jbc.REV120.013930
PMCID: PMC7489918
PMID: 32661197
Abstract
Few human pathogens have been the focus of as much concentrated worldwide attention as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its emergence into the human population and ensuing pandemic came on the heels of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), two other highly pathogenic coronavirus spillovers, which collectively have reshaped our view of a virus family previously associated primarily with the common cold. It has placed intense pressure on the collective scientific community to develop therapeutics and vaccines, whose engineering relies on a detailed understanding of coronavirus biology. Here, we present the molecular virology of coronavirus infection, including its entry into cells, its remarkably sophisticated gene expression and replication mechanisms, its extensive remodeling of the intracellular environment, and its multifaceted immune evasion strategies. We highlight aspects of the viral life cycle that may be amenable to antiviral targeting as well as key features of its biology that await discovery.
Details
- Title: Subtitle
- The molecular virology of coronaviruses
- Creators
- Ella Hartenian - University of California, BerkeleyDivya Nandakumar - University of California, BerkeleyAzra Lari - University of California, BerkeleyMichael Ly - University of California, BerkeleyJessica M. Tucker - University of California, BerkeleyBritt A. Glaunsinger - University of California, Berkeley
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.295(37), pp.12910-12934
- DOI
- 10.1074/jbc.REV120.013930
- PMID
- 32661197
- PMCID
- PMC7489918
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Publisher
- Elsevier
- Number of pages
- 25
- Grant note
- COVID-19 Excellence in Research Award from the Laboratory for Genomics Research PGSD3-5167872018 / Natural Sciences and Engineering Research Council of Canada (NSERC) CA136367 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 131370-PF-17-245-01-MPC / American Cancer Society
- Language
- English
- Date published
- 09/11/2020
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984297331302771
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