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The multicenter osteoarthritis study: Opportunities for rehabilitation research
Journal article   Peer reviewed

The multicenter osteoarthritis study: Opportunities for rehabilitation research

Neil A Segal, Michael C Nevitt, Keith D Gross, Jean Hietpas, Natalie A Glass, Cora E Lewis and James C Torner
PM & R, Vol.5(8), pp.647-654
2013
DOI: 10.1016/j.pmrj.2013.04.014
PMCID: PMC3867287
PMID: 23953013
url
http://doi.org/10.1016/j.pmrj.2013.04.014View
Open Access

Abstract

The Multicenter Osteoarthritis Study (MOST) is a longitudinal observational study of the effects of biomechanical, bone and joint structural, and nutritional factors on the incidence and progression of knee symptoms and radiographic and symptomatic knee osteoarthritis (OA). It is the first large-scale epidemiologic study to focus on symptomatic knee OA in a community-based sample of adultswith or at high risk for knee OA, based on thepresence of knee symptoms, history of knee injury or surgery or being overweight. Beginning in 2003, 3026 individuals (60.1% women) age 50-79 years were enrolled. Examinations at baseline, and 15, 30, 60, 72 and 84 months later included assessment of risk factors, disease characteristics, body functions and structure, and measures of physical activity and participation. The wealth of data from this longitudinal cohort of community-dwelling older adults affords valuable opportunities for rehabilitation researchers.

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