Journal article
The natural history of non-human GB virus C in captive chimpanzees
Journal of general virology, Vol.92(Pt 1), pp.91-100
01/2011
DOI: 10.1099/vir.0.026088-0
PMCID: PMC3052534
PMID: 20861317
Abstract
GB virus C (GBV-C) is a common, non-pathogenic human virus that infects lymphocytes. Persistent GBV-C infection of humans with coexistent human immunodeficiency virus (HIV) infection is associated with prolonged survival, and GBV-C replication inhibits HIV replication
in vitro
. A GBV-C virus variant was identified in chimpanzees in 1998 and was named GBV-C
trog
or GBV-C
cpz
. The prevalence and natural history of GBV-C in chimpanzees remains uncharacterized. We examined the sera from 235 captive chimpanzees for the presence of GBV-C viraemia, viral persistence and clearance, E2 antibody kinetics and RNA sequence diversity. Sequences from six isolates shared more sequence identity with GBV-C
cpz
than with human GBV-C. The prevalence of GBV-C
cpz
viraemia and E2 antibody in chimpanzees (2.5 and 11 %, respectively) was similar to human GBV-C prevalence in healthy human blood donors (1.8 and 9 %, respectively). Persistent GBV-C
cpz
infection occurred in two of the six viraemic animals and was documented for 19 years in one animal. Host subspecies
troglodyte
GBV-C isolates and published
verus
GBV-C isolates shared a high degree of sequence identity, suggesting that GBV-C in chimpanzees should be identified with a chimpanzee designation (GBV-C
cpz
). The prevalence and natural history of chimpanzee GBV-C variant (GBV-C
cpz
) appears to be similar to human GBV-C infection. The chimpanzee could serve as an animal model to study HIV–GBV-C co-infection.
Details
- Title: Subtitle
- The natural history of non-human GB virus C in captive chimpanzees
- Creators
- Emma L Mohr - Department of Internal Medicine, Division of Infectious Diseases, Iowa City Veterans Affairs Medical Center and The University of Iowa, Iowa City, IA 52242, USAKrishna K Murthy - Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USAJames H McLinden - Department of Internal Medicine, Division of Infectious Diseases, Iowa City Veterans Affairs Medical Center and The University of Iowa, Iowa City, IA 52242, USAJinhua Xiang - Department of Internal Medicine, Division of Infectious Diseases, Iowa City Veterans Affairs Medical Center and The University of Iowa, Iowa City, IA 52242, USAJack T Stapleton - Department of Internal Medicine, Division of Infectious Diseases, Iowa City Veterans Affairs Medical Center and The University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Journal of general virology, Vol.92(Pt 1), pp.91-100
- DOI
- 10.1099/vir.0.026088-0
- PMID
- 20861317
- PMCID
- PMC3052534
- NLM abbreviation
- J Gen Virol
- ISSN
- 0022-1317
- eISSN
- 1465-2099
- Publisher
- Society for General Microbiology
- Language
- English
- Date published
- 01/2011
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094211702771
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