Journal article
The nature of learning and memory impairments in schizophrenia
Journal of the International Neuropsychological Society, Vol.1(1), pp.88-99
01/1995
DOI: 10.1017/S135561770000014X
PMID: 9375213
Abstract
The California Verbal Learning Test was used to characterize the learning and memory impairment in schizophrenia (SC) and to evaluate potential clinical and demographic factors associated with this impairment. SC patients (n = 175) performed worse than normal comparison (NC) subjects (n = 229) on all learning, recall, and recognition memory measures. The most important clinical correlates of these impairments were earlier age of onset, more negative symptoms, and greater anticholinergic medication dosage. SC patients showed a prominent retrieval deficit as indicated by disproportionate improvement when tested in a recognition, rather than a free recall, format. A residual impairment seen with recognition testing suggests a mild encoding deficit as well. In contrast, the relative absence of a storage deficit is suggested by the lack of rapid forgetting. Using a discriminant function analysis that differentiates cortical dementia [i.e., Alzheimer's disease (AD)], subcortical dementia [i.e., Huntington's disease (HD)], and normals, it was found that 5070 of the SC patients were classified as having a subcortical memory profile and 35% were classified as having a normal profile, whereas only 15% were classified as having a cortical memory profile. Although these findings reflect the clinical heterogeneity often found in SC, results suggest that most SC patients demonstrate a pattern of learning and memory impairments that resembles the pattern seen in patients with primary subcortical (specifically striatal) pathology. (JINS, 1995, I, 88–99.)
Details
- Title: Subtitle
- The nature of learning and memory impairments in schizophrenia
- Creators
- Jane S Paulsen - 1Psychology Service, Veterans Affairs Medical Center, San Diego, CA 92161Robert K Heaton - 2Department of Psychiatry, University of California, San Diego, CA 92093Joseph R Sadek - 2Department of Psychiatry, University of California, San Diego, CA 92093William Perry - 2Department of Psychiatry, University of California, San Diego, CA 92093Dean C Delis - 1Psychology Service, Veterans Affairs Medical Center, San Diego, CA 92161David Braff - 2Department of Psychiatry, University of California, San Diego, CA 92093Julie Kuck - 2Department of Psychiatry, University of California, San Diego, CA 92093Sidney Zisook - 2Department of Psychiatry, University of California, San Diego, CA 92093Dilip V Jeste - 1Psychology Service, Veterans Affairs Medical Center, San Diego, CA 92161
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.1(1), pp.88-99
- Publisher
- Cambridge University Press
- DOI
- 10.1017/S135561770000014X
- PMID
- 9375213
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Number of pages
- 12
- Language
- English
- Date published
- 01/1995
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083812202771
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