Journal article
The network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancer
Breast cancer targets and therapy, Vol.7(default), pp.303-319
01/01/2015
DOI: 10.2147/BCTT.S71163
PMCID: PMC4567227
PMID: 26379447
Abstract
Breast cancer is the leading female cancer in terms of prevalence. Progress in molecular biology has brought forward a better understanding of its pathogenesis that has led to better prognostication and treatment. Subtypes of breast cancer have been identified at the genomic level and guide therapeutic decisions based on their biology and the expected benefit from various interventions. Despite this progress, a significant percentage of patients die from their disease and further improvements are needed. The cancer stem cell theory and the epithelial-mesenchymal transition are two comparatively novel concepts that have been introduced in the area of cancer research and are actively investigated. Both processes have their physiologic roots in normal development and common mediators have begun to surface. This review discusses the associations of these networks as a prognostic framework in breast cancer.
Details
- Title: Subtitle
- The network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancer
- Creators
- Ioannis A. Voutsadakis - Sault Area Hosp, Dept Internal Med, Div Med Oncol, 750 Great Northern Rd, Sault Ste Marie, ON P6B 0A8, Canada
- Resource Type
- Journal article
- Publication Details
- Breast cancer targets and therapy, Vol.7(default), pp.303-319
- DOI
- 10.2147/BCTT.S71163
- PMID
- 26379447
- PMCID
- PMC4567227
- NLM abbreviation
- Breast Cancer (Dove Med Press)
- ISSN
- 1179-1314
- eISSN
- 1179-1314
- Publisher
- Dove Medical Press Ltd
- Number of pages
- 17
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806601002771
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