The neural substrates of enhanced salt appetite after repeated sodium depletions

Elisa S Na; Michael J Morris; Ralph F Johnson; Terry G Beltz; Alan Kim Johnson

doi:10.1016/j.brainres.2007.07.033

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The neural substrates of enhanced salt appetite after repeated sodium depletions

Journal article

Peer reviewed

The neural substrates of enhanced salt appetite after repeated sodium depletions

Elisa S Na, Michael J Morris, Ralph F Johnson, Terry G Beltz and Alan Kim Johnson

Brain research, Vol.1171(1), pp.104-110

2007

DOI: 10.1016/j.brainres.2007.07.033

PMCID: PMC2774233

PMID: 17822683

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https://www.ncbi.nlm.nih.gov/pmc/articles/2774233View

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Abstract

Sodium appetite is associated with a form of behavioral plasticity in which animals experimentally depleted of sodium progressively increase their intake of hypertonic NaCl over several successive (on 2 to 4 occasions) depletion. The present experiment explored the nature of this plasticity by quantifying Fos immunoreactivity (Fos-ir) in structures implicated in the mediation of sodium appetite and in the signaling of reward. Rats were depleted of sodium with the diuretic furosemide three times (3F), one time (2V1F) or sham depleted (i.e., vehicle treated; 3V). Rats were given sodium appetite tests for the first two treatments. The sodium appetite test was omitted after the third treatment. Fos-ir activity was quantified in the paraventricular nucleus (PVN), subfornical organ (SFO), supraoptic nucleus (SON), nucleus accumbens (NAc) shell and core, basolateral (BLA) and central amygdala (CeA), and medial prefrontal cortex (mPFC). Animals receiving repeated sodium depletions increased sodium ingestion across initial depletions. Fos-ir activity was markedly enhanced in the SFO, BLA, and shell of the NAc of 3F rats relative to 2V1F and 3V animals. These results indicate that repeated experience with sodium depletion and ingestion affects both behavioral and neural responses to sodium. Experience with sodium depletion enhances its ingestion and may have a direct impact on central structures implicated in sodium appetite and reward signaling. © 2007 Elsevier B.V. All rights reserved.

Biological and medical sciences

Feeding. Feeding behavior

Fundamental and applied biological sciences. Psychology

Vertebrates: anatomy and physiology, studies on body, several organs or systems

Details

Title: Subtitle: The neural substrates of enhanced salt appetite after repeated sodium depletions
Creators: Elisa S Na - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242, United States
Michael J Morris - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242, United States
Ralph F Johnson - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242, United States
Terry G Beltz - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242, United States
Alan Kim Johnson - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242, United States
Resource Type: Journal article
Publication Details: Brain research, Vol.1171(1), pp.104-110
DOI: 10.1016/j.brainres.2007.07.033
PMID: 17822683
PMCID: PMC2774233
NLM abbreviation: Brain Res
ISSN: 0006-8993
eISSN: 1872-6240
Publisher: Elsevier
Language: English
Date published: 2007
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213418202771

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