Journal article
The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function
Epilepsia (Copenhagen), Vol.43(9), pp.1062-1071
09/2002
DOI: 10.1046/j.1528-1157.2002.49901.x
PMID: 12199732
Abstract
To characterize the neurodevelopmental correlates of childhood-onset temporal lobe epilepsy on brain structure and cognition compared with late-onset chronic temporal lobe epilepsy and healthy controls.
Healthy controls (n = 62) and patients with early (n = 37) versus late (n = 16) age at onset of temporal lobe epilepsy were compared with high-resolution quantitative magnetic resonance imaging (MRI) volumetrics and comprehensive neuropsychological assessment.
Patients with childhood-onset temporal lobe epilepsy (mean onset age, 7.8 years) exhibited widespread compromise in neuropsychological performance and substantial reduction in brain tissue volumes extending to extratemporal regions compared with healthy controls and late-onset temporal lobe epilepsy patients (mean onset age, 23.3 years). Most evident was reduced total white-matter volume among the childhood-onset patients. Reduction in brain tissue volume, especially total white-matter volume, was associated with significantly poorer cognitive status, attesting to the clinical significance of the volumetric abnormalities.
Childhood-onset temporal lobe epilepsy appears to be associated with an adverse neurodevelopmental impact on brain structure and cognition that appears generalized in nature and especially evident in white-matter tissue volume.
Details
- Title: Subtitle
- The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function
- Creators
- Bruce Hermann - Departments of Neurology and Radiology, University of Wisconsin, Madison, Wisconsin 53792, USA. hermann@neurology.wisc.eduMichael SeidenbergBrian BellPaul RuteckiRaj ShethKevin RugglesGary WendtDaniel O'LearyVincent Magnotta
- Resource Type
- Journal article
- Publication Details
- Epilepsia (Copenhagen), Vol.43(9), pp.1062-1071
- DOI
- 10.1046/j.1528-1157.2002.49901.x
- PMID
- 12199732
- NLM abbreviation
- Epilepsia
- ISSN
- 0013-9580
- eISSN
- 1528-1167
- Publisher
- United States
- Grant note
- NS-37738 / NINDS NIH HHS M01-RR03186 / NCRR NIH HHS
- Language
- English
- Date published
- 09/2002
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003476502771
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