The neuroendocrine impact of chronic stress on cancer

Premal H Thaker; Susan K Lutgendorf; Anil K Sood

doi:10.4161/cc.6.4.3829

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The neuroendocrine impact of chronic stress on cancer

Journal article

Open access

Peer reviewed

The neuroendocrine impact of chronic stress on cancer

Premal H Thaker, Susan K Lutgendorf and Anil K Sood

Cell cycle (Georgetown, Tex.), Vol.6(4), pp.430-433

02/15/2007

DOI: 10.4161/cc.6.4.3829

PMID: 17312398

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https://doi.org/10.4161/cc.6.4.3829View

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Abstract

Behavioral processes have long been suspected to influence many health processes including effects on cancer. However, mechanisms underlying these observations are not fully understood. Recent work has demonstrated that chronic behavioral stress results in higher levels of tissue catecholamines, greater tumor burden, and a more invasive pattern of ovarian cancer growth in an orthotopic mouse model. These effects are mediated primarily through the beta(2) adrenergic receptor (ADRB2) activation of the tumor cell cyclic AMP (cAMP)-protein kinase A (PKA) signaling pathway. Additionally, tumors in stressed animals have increased vascularization and enhanced expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) -2 and -9. In this review, we highlight the importance of the neuroendocrine stress response in tumor biology and discuss mechanisms by which the beta-adrenergic receptors on ovarian cancer cells enhance angiogenesis and tumor growth.

Cyclic AMP-Dependent Protein Kinases - metabolism

Receptors, Adrenergic, beta-2 - physiology

Signal Transduction

Matrix Metalloproteinase 2 - metabolism

Humans

Neovascularization, Pathologic

Vascular Endothelial Growth Factor A - metabolism

Carcinoma - etiology

Cyclic AMP-Dependent Protein Kinases - physiology

Matrix Metalloproteinase 9 - metabolism

Animals

Stress, Psychological - metabolism

Neurosecretory Systems - metabolism

Female

Carcinoma - blood supply

Mice

Ovarian Neoplasms - metabolism

Carcinoma - metabolism

Ovarian Neoplasms - blood supply

Ovarian Neoplasms - etiology

Stress, Psychological - complications

Details

Title: Subtitle: The neuroendocrine impact of chronic stress on cancer
Creators: Premal H Thaker - Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, USA
Susan K Lutgendorf
Anil K Sood
Resource Type: Journal article
Publication Details: Cell cycle (Georgetown, Tex.), Vol.6(4), pp.430-433
DOI: 10.4161/cc.6.4.3829
PMID: 17312398
NLM abbreviation: Cell Cycle
ISSN: 1538-4101
eISSN: 1551-4005
Publisher: United States
Grant note: CA11079301 / NCI NIH HHS CA104825 / NCI NIH HHS CA10929801 / NCI NIH HHS 2P50CA083639 / NCI NIH HHS
Language: English
Date published: 02/15/2007
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984065888602771

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