The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia

Kelly Davis Garrett; Jeffrey N Browndyke; William Whelihan; Robert H Paul; Margaret DiCarlo; David J Moser; Ronald A Cohen; Brian R Ott

doi:10.1016/j.acn.2003.09.008

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The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia

Kelly Davis Garrett, Jeffrey N Browndyke, William Whelihan, Robert H Paul, Margaret DiCarlo, David J Moser, Ronald A Cohen and Brian R Ott

Archives of clinical neuropsychology, Vol.19(6), pp.745-757

09/2004

DOI: 10.1016/j.acn.2003.09.008

PMID: 15288328

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Abstract

Hachinski and co-workers have used the term vascular cognitive impairment-no dementia (VaCIND) to represent the earliest stages of cognitive decline associated with vascular changes [Neurology 57 (4) (2001) 714]. However, the neuropsychological profile of vascular CIND remains unclear. Twenty-five healthy elders, 29 individuals at risk for cerebrovascular disease (R-CVD), 18 individuals with VaCIND, and 26 individuals with vascular dementia (VaD) were examined to determine whether patterns of neuropsychological assessment performance can assist in the differentiation of patients at varying levels of risk and severity for cerebrovascular disease and VaD. The R-CVD group performed within normal expectations on most cognitive measures as compared to the elderly control sample and published clinical norms. Relative to elderly controls, the VaCIND group demonstrated significant difficulties on measures of cognitive flexibility, verbal retrieval, and verbal recognition memory, but not on measures of confrontational naming or verbal fluency. The VaD group was impaired on all cognitive measures assessed. The current findings suggest that poor cognitive flexibility and verbal retrieval in the context of preserved function in other domains may characterize the prodromal stage of VaD.

Dementia, Vascular - psychology

Reproducibility of Results

Comorbidity

Health Status Indicators

Psychometrics - statistics & numerical data

Humans

Middle Aged

Cerebral Infarction - diagnosis

Male

Reference Values

Mental Status Schedule - statistics & numerical data

Cognition Disorders - diagnosis

Dementia, Vascular - diagnosis

Neuropsychological Tests - statistics & numerical data

Brain Ischemia - psychology

Aged, 80 and over

Brain Ischemia - diagnosis

Cerebral Infarction - psychology

Female

Aged

Cardiovascular Diseases - psychology

Cardiovascular Diseases - diagnosis

Cognition Disorders - psychology

Details

Title: Subtitle: The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia
Creators: Kelly Davis Garrett - Department of Psychiatry and Human Behavior, Brown Medical School, USA. kelly@drexel.edu
Jeffrey N Browndyke
William Whelihan
Robert H Paul
Margaret DiCarlo
David J Moser
Ronald A Cohen
Brian R Ott
Resource Type: Journal article
Publication Details: Archives of clinical neuropsychology, Vol.19(6), pp.745-757
Publisher: United States
DOI: 10.1016/j.acn.2003.09.008
PMID: 15288328
ISSN: 0887-6177
eISSN: 1873-5843
Language: English
Date published: 09/2004
Academic Unit: Psychiatry; Medicine Administration
Record Identifier: 9984003443502771

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