Journal article
The nitrilase superfamily: classification, structure and function
Genome biology, Vol.2(1), reviews0001.1
2001
DOI: 10.1186/gb-2001-2-1-reviews0001
PMCID: PMC150437
PMID: 11380987
Abstract
The nitrilase superfamily consists of thiol enzymes involved in natural product biosynthesis and post-translational modification in plants, animals, fungi and certain prokaryotes. On the basis of sequence similarity and the presence of additional domains, the superfamily can be classified into 13 branches, nine of which have known or deduced specificity for specific nitrile- or amide-hydrolysis or amide-condensation reactions. Genetic and biochemical analysis of the family members and their associated domains assists in predicting the localization, specificity and cell biology of hundreds of uncharacterized protein sequences.
Details
- Title: Subtitle
- The nitrilase superfamily: classification, structure and function
- Creators
- H C Pace - Structural Biology and Bioinformatics Program, Kimmel Cancer Center, 233 S Tenth Street, Philadelphia, PA 19107, USAC Brenner
- Resource Type
- Journal article
- Publication Details
- Genome biology, Vol.2(1), reviews0001.1
- Publisher
- England
- DOI
- 10.1186/gb-2001-2-1-reviews0001
- PMID
- 11380987
- PMCID
- PMC150437
- ISSN
- 1474-760X
- eISSN
- 1474-760X
- Grant note
- P01 CA077738-020003 / NCI NIH HHS P01 CA077738 / NCI NIH HHS P01CA77738 / NCI NIH HHS
- Language
- English
- Date published
- 2001
- Academic Unit
- Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9983788598402771
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