Journal article
The oral and craniofacial relevance of chemically modified RNA therapeutics
Discovery medicine, Vol.21(113), pp.35-39
01/2016
DOI: 10.15496/publikation-18263
PMCID: PMC4830726
PMID: 26896600
Abstract
Several tissue engineering strategies in the form of protein therapy, gene therapy, cell therapy, and their combinations are currently being explored for oral and craniofacial regeneration and repair. Though each of these approaches has advantages, they all have common inherent drawbacks of being expensive and raising safety concerns. Using RNA (encoding therapeutic protein) has several advantages that have the potential to overcome these limitations. Chemically modifying the RNA improves its stability and mitigates immunogenicity allowing for the potential of RNA to become an alternative to protein and gene based therapies. This brief review article focuses on the potential of RNA therapeutics in the treatment of disorders in the oral and craniofacial regions.
Details
- Title: Subtitle
- The oral and craniofacial relevance of chemically modified RNA therapeutics
- Creators
- Satheesh Elangovan - Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242, USAMichael S D Kormann - Department of Pediatrics I-Pediatric Infectiology, Immunology and Cystic Fibrosis, Translational Genomics and Gene Therapy, Wilhelmstr. 56, 72074 Tübingen, GermanyBehnoush Khorsand - Division of Pharmaceutics and Translational Therapeutics, University of Iowa College of Pharmacy, Iowa City, IA 52242, USAAliasger K Salem - Division of Pharmaceutics and Translational Therapeutics, University of Iowa College of Pharmacy, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Discovery medicine, Vol.21(113), pp.35-39
- DOI
- 10.15496/publikation-18263
- PMID
- 26896600
- PMCID
- PMC4830726
- NLM abbreviation
- Discov Med
- ISSN
- 1539-6509
- eISSN
- 1944-7930
- Grant note
- 1R21DE024206-01A1 / NIDCR NIH HHS R21 DE024206 / NIDCR NIH HHS
- Language
- English
- Date published
- 01/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Periodontics
- Record Identifier
- 9984216711302771
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