Journal article
The orphan granzymes of humans and mice
Current opinion in immunology, Vol.15(5), pp.544-552
10/2003
DOI: 10.1016/S0952-7915(03)00099-2
PMID: 14499263
Abstract
The granzyme/perforin pathway is a central pathway for lymphocyte-mediated killing in both the innate and adaptive immune systems. This pathway is important in a variety of host defenses, including viral clearance and tumor cell killing, and its dysregulation results in several human and rodent diseases. To date, the majority of reports in this field have concentrated on the functions of granzymes A and B. Recent reports, however, suggest that the non-A/non-B 'orphan' granzymes found in both humans and mice are potentially significant. Although the functions of these orphan granzymes have yet to be fully established, initial data suggests their importance in both immune and nonimmune cells.
Details
- Title: Subtitle
- The orphan granzymes of humans and mice
- Creators
- William J Grossman - Department of Pediatrics, Hale Irwin Center for Pediatric Oncology, #1 St Louis Children's Hospital, St Louis, MO 63110, USAPaula A RevellZhi Hong LuHillary JohnsonAndrew J BredemeyerTimothy J Ley
- Resource Type
- Journal article
- Publication Details
- Current opinion in immunology, Vol.15(5), pp.544-552
- Publisher
- England
- DOI
- 10.1016/S0952-7915(03)00099-2
- PMID
- 14499263
- ISSN
- 0952-7915
- eISSN
- 1879-0372
- Grant note
- 5T32 H007499 / PHS HHS DK 49786 / NIDDK NIH HHS
- Language
- English
- Date published
- 10/2003
- Academic Unit
- Dermatology
- Record Identifier
- 9984025564202771
Metrics
23 Record Views