Journal article
The pathology of posterior amorphous corneal dystrophy
Ophthalmology (Rochester, Minn.), Vol.97(1), pp.104-109
01/1990
DOI: 10.1016/S0161-6420(90)32638-6
PMID: 2314832
Abstract
The youngest affected member of a family with a five-generation history of posterior amorphous corneal dystrophy underwent penetrating keratoplasty. The corneal button was studied by light and electron microscopy, representing the first pathologic description of this condition. Light microscopy demonstrated fracturing of the most posterior collagen layers of the stroma and focal attenuation of endothelial cells. Electron microscopy showed the collagen fibers in the most posterior stromal lamellae to be disorganized. Descemet's layer was interrupted by a band of collagen fibers resembling stroma, and there was loss of endothelial cells. These findings suggest a developmental abnormality in the formation of the posterior stroma and Descemet's membrane in posterior amorphous corneal dystrophy.
Details
- Title: Subtitle
- The pathology of posterior amorphous corneal dystrophy
- Creators
- A Tim Johnson - Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City 52242Robert FolbergMichael P VrabecGeorge J FlorakisEdwin M StoneJay H Krachmer
- Resource Type
- Journal article
- Publication Details
- Ophthalmology (Rochester, Minn.), Vol.97(1), pp.104-109
- DOI
- 10.1016/S0161-6420(90)32638-6
- PMID
- 2314832
- NLM abbreviation
- Ophthalmology
- ISSN
- 0161-6420
- eISSN
- 1549-4713
- Publisher
- United States
- Language
- English
- Date published
- 01/1990
- Academic Unit
- Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979903802771
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