Journal article
The pathophysiology of acute pain: animal models
Current opinion in anaesthesiology, Vol.24(5), pp.508-514
10/01/2011
DOI: 10.1097/ACO.0b013e32834a50d8
PMCID: PMC3259564
PMID: 21841478
Abstract
Purpose of review
Trauma, surgery, and burns are three common clinical scenarios that are associated with significant acute pain. This review describes the pathophysiology of acute pain utilizing three preclinical models: surgery, burn, and fracture.
Recent findings
In general, there is greater interest directed toward peripheral mediators of acute pain. Studies indicate that treatment against nerve growth factor, interleukins, and ischemic-like mediators may provide valuable avenues for treatment of acute pain. By targeting the periphery, analgesic therapies may have reduced side-effects.
Summary
Peripheral mediators of acute pain can vary depending upon the type of injury. Treatment aimed toward those mediators specific to the injury may improve acute pain management in the future. It will be important to translate these findings into clinical trials in the future.
Details
- Title: Subtitle
- The pathophysiology of acute pain: animal models
- Creators
- Jun Xu - Abbott (United States)Timothy J. Brennan - Univ Iowa Hosp & Clin, Dept Anesthesia, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in anaesthesiology, Vol.24(5), pp.508-514
- DOI
- 10.1097/ACO.0b013e32834a50d8
- PMID
- 21841478
- PMCID
- PMC3259564
- NLM abbreviation
- Curr Opin Anaesthesiol
- ISSN
- 0952-7907
- eISSN
- 1473-6500
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- Galleon Pharmaceuticals Kai Pharmaceuticals Department of Anesthesia at the University of Iowa GM-55831 / National Institutes of Health, Bethesda, Maryland; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Adynxx, Inc. R01GM055831 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Hydra Biosciences and Ironwood Pharmaceuticals
- Language
- English
- Date published
- 10/01/2011
- Academic Unit
- Surgery; Anesthesia
- Record Identifier
- 9984322819002771
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