Journal article
The pharmacokinetics of hyperpolarized xenon: Implications for cerebral MRI
Journal of magnetic resonance imaging, Vol.7(5), pp.848-854
09/1997
DOI: 10.1002/jmri.1880070512
PMID: 9307910
Abstract
In this work, a compartmental model to predict the concentration of hyperpolarized xenon (Xe) in the brain is developed based on the well established kinetics of Xe and estimated T1 values for the compartments. For the gaseous compartments, T1 was set to 12 seconds. For the tissue compartments, T1 was set to 6 seconds. Three gas delivery techniques were modeled: hyperventilation followed by breath-hold, continual breathing, and hyperventilation followed by continual breathing. Based on Xe CT, it is estimated that the maximum concentration of Xe that could be breathed is 80%. Based on this value and the estimated maximum polarization of 50%, the peak gray matter concentration of hyperpolarized Xe is calculated to be .036 mM. This leads to an estimated signal-to-noise ratio (SNR), at 2 T, for hyperpolarized Xe that is a factor of 50 lower than the SNR for proton MRI. The peak concentration of hyperpolarized Xe was also calculated over a wide range of gas and tissue T1 values. This model also predicts that the arterial blood will have a concentration of hyperpolarized Xe that is 10 times greater than the concentration in gray matter. An interactive version of the model can be found on the World Wide Web at http:(/)/ric.uthscsa.edu/staff /charlesmartinphd.html.
Details
- Title: Subtitle
- The pharmacokinetics of hyperpolarized xenon: Implications for cerebral MRI
- Creators
- Charles C Martin - Research Imaging Center, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284Robert F Williams - Research Imaging Center, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284Jia-Hong Gao - Research Imaging Center, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284Lisa D. H Nickerson - Research Imaging Center, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284Jinhu Xiong - Research Imaging Center, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284Peter T Fox - Research Imaging Center, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.7(5), pp.848-854
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/jmri.1880070512
- PMID
- 9307910
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Number of pages
- 7
- Language
- English
- Date published
- 09/1997
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984083875502771
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