Journal article
The physiological effects of hyperosmolar resuscitation: 5% vs 3% hypertonic saline
The American journal of surgery, Vol.208(5), pp.697-702
11/01/2014
DOI: 10.1016/j.amjsurg.2014.01.009
PMID: 24928332
Abstract
Use of 5% normal saline (NS) is gaining renewed interest. The primary aim of our study was to compare the physiological effects after the administration of different concentrations of hypertonic saline (3% vs 5%NS) in the initial resuscitation of trauma.
We performed a retrospective analysis of a prospectively collected database of all trauma patients who received hypertonic saline during initial resuscitation. Medical records were reviewed for serum electrolytes and serum osmolarity, coagulation parameters, complications, and mortality.
A total of 212 patients were included in the study, of which 170 patients received 5%NS and 42 patients received 3%NS. Both groups were similar in age (41.16 ± 19 vs 44.17 + 23.6; P = .45) and ISS score (26 [17 to 29] vs 25 [16 to 27]; P = .6). Mean serum osmolarity (316 ± 20.3 vs 294 ± 22.5; P = .02) and serum sodium levels (143 ± 8.6 vs 137 ± 10.9; P < .001) remained higher in the 5%NS group within 72 hours of admission. The pH was lower in the 5%NS group compared with the 3%NS group at 24 hours (7.29 ± .12 vs 7.33 ± .12; P = .01); however, at 48 and 72 hours (7.40 ± .07 vs 7.41 ± .07; P = .7), no difference was found. There was no difference in blood products requirement (1,734 vs 2,253 mL; P = .11) between the 2 groups.
The 5%NS has sustained higher serum osmolarity and serum sodium concentration within the first 72 hours without any increase in adverse effects in comparison with 3%NS.
Details
- Title: Subtitle
- The physiological effects of hyperosmolar resuscitation: 5% vs 3% hypertonic saline
- Creators
- Bellal Joseph - University of ArizonaHassan Aziz - University of ArizonaMargeaux Snell - University of ArizonaViraj Pandit - University of ArizonaDaniel Hays - University of ArizonaNarong Kulvatunyou - University of ArizonaAndrew Tang - University of ArizonaTerence O'Keeffe - University of ArizonaJulie Wynne - University of ArizonaRandall S Friese - University of ArizonaPeter Rhee - University of Arizona
- Resource Type
- Journal article
- Publication Details
- The American journal of surgery, Vol.208(5), pp.697-702
- DOI
- 10.1016/j.amjsurg.2014.01.009
- PMID
- 24928332
- ISSN
- 0002-9610
- eISSN
- 1879-1883
- Language
- English
- Date published
- 11/01/2014
- Academic Unit
- Surgery
- Record Identifier
- 9984701554702771
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