The piglet as a model for B cell and immune system development

J.E Butler; K.M Lager; I Splichal; D Francis; I Kacskovics; M Sinkora; N Wertz; J Sun; Y Zhao; W.R Brown; R DeWald; S Dierks; S Muyldermans; J.K Lunney; P.B McCray; C.S Rogers; M.J Welsh; P Navarro; F Klobasa; F Habe; J Ramsoondar

doi:10.1016/j.vetimm.2008.10.321

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The piglet as a model for B cell and immune system development

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The piglet as a model for B cell and immune system development

J.E Butler, K.M Lager, I Splichal, D Francis, I Kacskovics, M Sinkora, N Wertz, J Sun, Y Zhao, W.R Brown, …

Veterinary immunology and immunopathology, Vol.128(1-3), pp.147-170

03/15/2009

DOI: 10.1016/j.vetimm.2008.10.321

PMCID: PMC2828348

PMID: 19056129

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Abstract

The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adaptive immune response of neonates. Studies on laboratory rodents or primates have been ambiguous because neither the effect of environmental nor maternal factors on the newborn can be controlled in mammals that: (i) transmit potential maternal immunoregulatory factors in utero and (ii) are altricial and cannot be reared after birth without their mothers. Employing the newborn piglet model can address each of these concerns. However, it comes at the price of having first to characterize the immune system of swine and its development. This review focuses on the porcine B cell system, especially on the methods used for its characterization in fetal studies and neonatal piglets. Understanding these procedures is important in the interpretation of the data obtained. Studies on neonatal piglets have (a) provided valuable information on the development of the adaptive immune system, (b) lead to important advances in evolutionary biology, (c) aided our understanding of passive immunity and (d) provided opportunities to use swine to address specific issues in veterinary and biomedical research and immunotherapy. This review summarizes the history of the development of the piglet as a model for antibody repertoire development, thus providing a framework to guide future investigators.

Gnotobiotic

Models

Developmental immunology

Review

Swine

Details

Title: Subtitle: The piglet as a model for B cell and immune system development
Creators: J.E Butler - Department of Microbiology, University of Iowa, Iowa City, IA, United States
K.M Lager - National Animal Disease Center, ARS, USDA, Ames, IA, United States
I Splichal - Institute of Microbiology, Academy of Science of the Czech Republic, Novy Hradek, Czech Republic
D Francis - South Dakota State University
I Kacskovics - Department of Immunology, Institute of Biology, Eotvos Lorand University, Budapest, Hungary
M Sinkora - Institute of Microbiology, Academy of Science of the Czech Republic, Novy Hradek, Czech Republic
N Wertz - Department of Microbiology, University of Iowa, Iowa City, IA, United States
J Sun - Wake Forest University, Winston-Salem, NC, United States
Y Zhao - State Key Laboratories for AgroBiotechnology, College of Biological Sciences, China Agricultural University, Beijing, PR China
W.R Brown - Abbott Laboratories, North Chicago, IL, United States
R DeWald - Center for Veterinary Biologics, National Veterinary Services Laboratory, Ames, IA, United States
S Dierks - Abbott Laboratories, North Chicago, IL, United States
S Muyldermans - Laboratory of Cellular and Molecular Immunology, Free University of Brussels, Belgium
J.K Lunney - ANRI, ARS, USDA, Beltsville, MD, United States
P.B McCray - Department of Pediatrics, University of Iowa, Iowa City, IA, United States
C.S Rogers - Department of Internal Medicine, University of Iowa, Iowa City, IA, United States
M.J Welsh - Department of Internal Medicine, University of Iowa, Iowa City, IA, United States
P Navarro - Pioneer Research, Johnston, IA, United States
F Klobasa - Institut fuer Tierzucht u. Tierenverhalten, FAL, Mariensee, Germany
F Habe - Zootechnical Department, University of Ljubljana, Domzale, Slovenia
J Ramsoondar - Revivicor, Blacksburg, VA, United States
Resource Type: Journal article
Publication Details: Veterinary immunology and immunopathology, Vol.128(1-3), pp.147-170
DOI: 10.1016/j.vetimm.2008.10.321
PMID: 19056129
PMCID: PMC2828348
NLM abbreviation: Vet Immunol Immunopathol
ISSN: 0165-2427
eISSN: 1873-2534
Publisher: Elsevier B.V
Language: English
Date published: 03/15/2009
Academic Unit: Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Neurosurgery; Internal Medicine
Record Identifier: 9984093506602771

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