Journal article
The polyomavirus puzzle: is host immune response beneficial in controlling BK virus after adult hematopoietic cell transplantion?
Transplant infectious disease, Vol.16(4), pp.521-531
08/01/2014
DOI: 10.1111/tid.12233
PMCID: PMC4126842
PMID: 24834968
Abstract
BK virus (BKV), a ubiquitous human polyomavirus, usually does not cause disease in healthy individuals. BKV reactivation and disease can occur in immunosuppressed individuals, such as those who have undergone renal transplantation or hematopoietic cell transplantation (HCT). Clinical manifestations of BKV disease include graft dysfunction and failure in renal transplant recipients; HCT recipients frequently experience hematuria, cystitis, hemorrhagic cystitis (HC), and renal dysfunction. Studies of HCT patients have identified several risk factors for the development of BKV disease including myeloablative conditioning, acute graft-versus-host disease, and undergoing an umbilical cord blood (uCB) HCT. Although these risk factors indicate that alterations in the immune system are necessary for BKV pathogenesis in HCT patients, few studies have examined the interactions between host immune responses and viral reactivation in BKV disease. Specifically, having BKV immunoglobulin-G before HCT does not protect against BKV infection and disease after HCT. A limited number of studies have demonstrated BKV-specific cytotoxic T cells in healthy adults as well as in post-HCT patients who had experienced HC. New areas of research are required for a better understanding of this emerging infectious disease post HCT, including prospective studies examining BK viruria, viremia, and their relationship with clinical disease, a detailed analysis of urothelial histopathology, and laboratory evaluation of systemic and local cellular and humoral immune responses to BKV in patients receiving HCT from different sources, including uCB and haploidentical donors.
Details
- Title: Subtitle
- The polyomavirus puzzle: is host immune response beneficial in controlling BK virus after adult hematopoietic cell transplantion?
- Creators
- G. Satyanarayana - Beth Israel Deaconess Medical CenterF. M. Marty - Brigham and Women's HospitalC. S. Tan - Beth Israel Deaconess Medical Center
- Resource Type
- Journal article
- Publication Details
- Transplant infectious disease, Vol.16(4), pp.521-531
- DOI
- 10.1111/tid.12233
- PMID
- 24834968
- PMCID
- PMC4126842
- NLM abbreviation
- Transpl Infect Dis
- ISSN
- 1398-2273
- eISSN
- 1399-3062
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- K08 NS 064215-01 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K08NS064215 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 08/01/2014
- Academic Unit
- Iowa Neuroscience Institute; Internal Medicine
- Record Identifier
- 9984366287002771
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