Journal article
The porcine lung as a potential model for cystic fibrosis
American journal of physiology. Lung cellular and molecular physiology, Vol.295(2), pp.L240-L263
08/2008
DOI: 10.1152/ajplung.90203.2008
PMCID: PMC2519845
PMID: 18487356
Abstract
Airway disease currently causes most of the morbidity and mortality in patients with cystic fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing novel therapeutic strategies have been hampered by the limitations of current models. Although the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) has been targeted in mice, CF mice fail to develop lung or pancreatic disease like that in humans. In many respects, the anatomy, biochemistry, physiology, size, and genetics of pigs resemble those of humans. Thus pigs with a targeted
CFTR
gene might provide a good model for CF. Here, we review aspects of porcine airways and lung that are relevant to CF.
Details
- Title: Subtitle
- The porcine lung as a potential model for cystic fibrosis
- Creators
- Christopher S Rogers - Department of Internal MedicineWilliam M Abraham - Department of Internal MedicineKim A Brogden - Department of Internal MedicineJohn F Engelhardt - Department of Internal MedicineJohn T Fisher - Department of Internal MedicinePaul B McCray - Department of Internal MedicineGeoffrey McLennan - Department of Internal MedicineDavid K Meyerholz - Department of Internal MedicineEman Namati - Department of Internal MedicineLynda S Ostedgaard - Department of Internal MedicineRandall S Prather - Department of Internal MedicineJuan R Sabater - Department of Internal MedicineDavid Anthony Stoltz - Department of Internal MedicineJoseph Zabner - Department of Internal MedicineMichael J Welsh - Department of Internal Medicine
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Lung cellular and molecular physiology, Vol.295(2), pp.L240-L263
- DOI
- 10.1152/ajplung.90203.2008
- PMID
- 18487356
- PMCID
- PMC2519845
- NLM abbreviation
- Am J Physiol Lung Cell Mol Physiol
- ISSN
- 1040-0605
- eISSN
- 1522-1504
- Publisher
- American Physiological Society
- Language
- English
- Date published
- 08/2008
- Academic Unit
- Neurology; Microbiology and Immunology; Pathology; Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Pulmonary Medicine; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Radiation Oncology; Neurosurgery; Periodontics; Internal Medicine
- Record Identifier
- 9984025463202771
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