Journal article
The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study
Aging (Albany, NY.), Vol.14, pp.8927-8943
11/18/2022
DOI: 10.18632/aging.204393
PMCID: PMC9740381
PMID: 36399107
Abstract
PURPOSEMetformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lower delirium risk, as well as long-term mortality. METHODSIn this retrospective cohort study, previously recruited 1,404 subjects were analyzed. The relationship between metformin use and delirium, and the relationship between metformin use and 3-year mortality were investigated. MAIN FINDINGS242 subjects were categorized into a type 2 diabetes mellitus (DM)-without-metformin group, and 264 subjects were categorized into a DM-with-metformin group. Prevalence of delirium was 36.0% in the DM-without-metformin group, and 29.2% in the DM-with-metformin group. A history of metformin use reduced the risk of delirium in patients with DM (OR, 0.50 [95% CI, 0.32 to 0.79]) after controlling for confounding factors. The 3-year mortality in the DM-without-metformin group (survival rate, 0.595 [95% CI, 0.512 to 0.669]) was higher than in the DM-with-metformin group (survival rate, 0.695 [95% CI, 0.604 to 0.770]) (p=0.035). A history of metformin use decreased the risk of 3-year mortality after adjustment for confounding factors (HR, 0.69 [95% CI, 0.48 to 0.98]). CONCLUSIONSMetformin use may lower the risk of delirium and mortality in DM patients.
Details
- Title: Subtitle
- The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study
- Creators
- Takehiko Yamanashi - Stanford UniversityZoe-Ella Em Anderson - Roy J. and Lucille A. Carver College of MedicineManisha Modukuri - Roy J. and Lucille A. Carver College of MedicineGloria Chang - Roy J. and Lucille A. Carver College of MedicineTammy Tran - Roy J. and Lucille A. Carver College of MedicinePedro S Marra - Roy J. and Lucille A. Carver College of MedicineNadia E Wahba - Roy J. and Lucille A. Carver College of MedicineKaitlyn J Crutchley - Roy J. and Lucille A. Carver College of MedicineEleanor J Sullivan - Roy J. and Lucille A. Carver College of MedicineSydney S Jellison - Roy J. and Lucille A. Carver College of MedicineKatie R Comp - Roy J. and Lucille A. Carver College of MedicineCade C Akers - Roy J. and Lucille A. Carver College of MedicineAlissa A Meyer - Roy J. and Lucille A. Carver College of MedicineSangil Lee - Roy J. and Lucille A. Carver College of MedicineMasaaki Iwata - Tottori UniversityHyunkeun R Cho - University of IowaEri Shinozaki - Roy J. and Lucille A. Carver College of MedicineGen Shinozaki - Stanford University
- Resource Type
- Journal article
- Publication Details
- Aging (Albany, NY.), Vol.14, pp.8927-8943
- DOI
- 10.18632/aging.204393
- PMID
- 36399107
- PMCID
- PMC9740381
- NLM abbreviation
- Aging (Albany NY)
- eISSN
- 1945-4589
- Language
- English
- Date published
- 11/18/2022
- Academic Unit
- Psychiatry; Emergency Medicine; Iowa Neuroscience Institute; Biostatistics; Injury Prevention Research Center; General Internal Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984319357502771
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