Journal article
The potential role of angiotensin converting enzyme and vasopeptidase inhibitors in the treatment of diabetic neuropathy
Current drug targets, Vol.9(1), pp.77-84
01/01/2008
DOI: 10.2174/138945008783431736
PMID: 18220715
Abstract
Diabetic neuropathy is a debilitating disorder that occurs in more than 50 percent of patients with diabetes. Evidence suggests that there are at least five major pathways involved in the development of diabetic neuropathy: metabolic, vascular, immunologic, neurohormonal growth factor deficiency, and extracellular matrix remodeling. In light of the complicated etiologies, an effective treatment for diabetic neuropathy has not yet been identified. Hyperglycemia increases tissue angiotensin II, which induces oxidative stress, endothelial damage and other pathologies including vasoconstriction, thrombosis, inflammation and vascular remodeling. Angiotensin converting enzyme inhibition and/or blocking of the angiotensin II receptor are recognized as first line treatment for nephropathy and cardiovascular disease in diabetes patients. A new class of drug in late stages of development is vasopeptidase inhibitors. This drug inhibits both angiotensin converting enzyme activity and neutral endopeptidase. Neutral endopeptidase is a protease that degrades a number of biologically active peptides including vasoactive peptides. However, little information is available about the potential benefits of these drugs on diabetic neuropathy. Pre-clinical studies suggest that these drugs may be useful in treating diabetic complications involving vascular tissue. The purpose of this review is to evaluate the use of angiotensin converting enzyme and vasopeptidase inhibitors in the treatment of diabetic neuropathy.
Details
- Title: Subtitle
- The potential role of angiotensin converting enzyme and vasopeptidase inhibitors in the treatment of diabetic neuropathy
- Creators
- Mark A. Yorek - Department of Internal Medicine, University of Iowa and Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA, 52246, USA.
- Resource Type
- Journal article
- Publication Details
- Current drug targets, Vol.9(1), pp.77-84
- Publisher
- Bentham Science Publ Ltd
- DOI
- 10.2174/138945008783431736
- PMID
- 18220715
- ISSN
- 1389-4501
- eISSN
- 1873-5592
- Number of pages
- 8
- Grant note
- DK073990; R56 DK073990 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01DK073990 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 01/01/2008
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359855802771
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