Journal article
The potential to use PspA and other pneumococcal proteins to elicit protection against pneumococcal infection
Vaccine, Vol.18(16), pp.1707-1711
2000
DOI: 10.1016/S0264-410X(99)00511-3
PMID: 10689153
Abstract
Pneumococcal proteins, alone, in combination with each other, or in combination with capsular polysaccharide–protein conjugates may be useful pneumococcal vaccine components. Four proteins with a potential for use in vaccines are PspA, pneumolysin, PsaA, and PspC. In a mouse model of carriage, PsaA and PspC were the most efficacious vaccine proteins. Of these, PsaA was the best at eliciting protection against carriage. However, a combination of PspA and pneumolysin may elicit stronger immunity to pulmonary infection and possibly sepsis than either protein alone. Recently, a phase one trial of a recombinant family 1 PspA was completed in man. PspA was observed to be safe and immunogenic. Injection of 0.1 ml of immune serum diluted to 1/400 was able to protect mice from fatal infection with
S. pneumoniae. Under these conditions, pre-immune serum was not protective. The immune human serum protected mice from infections with pneumococci expressing either of the major PspA families (1 and 2) and both of the pneumococcal capsular types tested: 3 and 6.
Details
- Title: Subtitle
- The potential to use PspA and other pneumococcal proteins to elicit protection against pneumococcal infection
- Creators
- David E Briles - Department of Microbiology, University of Alabama at Birmingham, 658 BBLB, 845 19th Street South, Birmingham, AL 35294, USASusan Hollingshead - Department of Microbiology, University of Alabama at Birmingham, 658 BBLB, 845 19th Street South, Birmingham, AL 35294, USAAlexis Brooks-Walter - Department of Microbiology, University of Alabama at Birmingham, 658 BBLB, 845 19th Street South, Birmingham, AL 35294, USAGary S Nabors - Aventis Pasteur, Discovery Drive, Swiftwater, PA, 18370 USALaura Ferguson - Aventis Pasteur, Discovery Drive, Swiftwater, PA, 18370 USAMargo Schilling - The Glennam Center for Geriatrics, Eastern Virginia Medical School, 201 Hofheimer Hall, 825 Fairfax Norfolk, VA, USAStephan Gravenstein - The Glennam Center for Geriatrics, Eastern Virginia Medical School, 201 Hofheimer Hall, 825 Fairfax Norfolk, VA, USAPat Braun - Aventis Pasteur, Discovery Drive, Swiftwater, PA, 18370 USAJanice King - Department of Microbiology, University of Alabama at Birmingham, 658 BBLB, 845 19th Street South, Birmingham, AL 35294, USAAmy Swift - Department of Microbiology, University of Alabama at Birmingham, 658 BBLB, 845 19th Street South, Birmingham, AL 35294, USA
- Resource Type
- Journal article
- Publication Details
- Vaccine, Vol.18(16), pp.1707-1711
- DOI
- 10.1016/S0264-410X(99)00511-3
- PMID
- 10689153
- NLM abbreviation
- Vaccine
- ISSN
- 0264-410X
- eISSN
- 1873-2518
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2000
- Academic Unit
- Family and Community Medicine; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984025260102771
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