The predictive utility of the in utero exposome for childhood adiposity in independent and integrated frameworks

Jonathan VanHawkins; Ryan Peterson; Kylie Harrall; Brandy Moon; Dana Dabelea; Katerina Kechris; Wei Perng

doi:10.1111/ijpo.13172

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The predictive utility of the in utero exposome for childhood adiposity in independent and integrated frameworks

Journal article

Peer reviewed

The predictive utility of the in utero exposome for childhood adiposity in independent and integrated frameworks

Jonathan VanHawkins, Ryan Peterson, Kylie Harrall, Brandy Moon, Dana Dabelea, Katerina Kechris and Wei Perng

Pediatric obesity, Vol.19(12), pp.e13172-n/a

12/01/2024

DOI: 10.1111/ijpo.13172

PMCID: PMC11560695

PMID: 39327854

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https://pmc.ncbi.nlm.nih.gov/articles/PMC11560695/pdf/nihms-2021322.pdfView

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Abstract

ObjectivesTo assess the predictive potential of the in utero exposome in relation to childhood adiposity as indicated by body mass index z-scores (BMIz) and the fourth versus first quartile of % fat mass (FM) at median age of 4.6 years.MethodsWe leveraged data on clinical risk factors for childhood obesity during the perinatal period, along with cord blood per/polyfluoroalkyl substances (PFAS) and cord blood DNA methylation, in 268 mother-offspring pairs. We used the sparsity ranked LASSO penalized regression framework for each outcome and assessed model performance based on % variability explained for BMIz and area under the receiver operating characteristic curve (AUC) for the fourth versus first quartile of %FM. We employed cross-validation for model tuning and split-sample validation for model evaluation.ResultsMean +/- SD BMIz was 0.01 +/- 1.1, %FM was 19.8 +/- 6.34%. The optimal model for predicting BMIz explained 19.1% of the variability in the validation set and included only clinical characteristics: maternal pre-pregnancy BMI, paternal BMI, gestational weight gain, physical activity during pregnancy and child race/ethnicity. The optimal model for fourth versus first quartiles of %FM achieved an AUC of 0.82 +/- 0.01 in the validation set, with the clinical features again emerging as the strongest predictors.ConclusionIn this study sample, perinatal chemical exposures and the epigenome have low utility in predicting childhood adiposity, beyond known clinical risk factors.

Life Sciences & Biomedicine

Pediatrics

Science & Technology

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Title: Subtitle: The predictive utility of the in utero exposome for childhood adiposity in independent and integrated frameworks
Creators: Jonathan VanHawkins - Colorado School of Public Health
Ryan Peterson - University of Colorado Anschutz Medical Campus
Kylie Harrall - Colorado School of Public Health
Brandy Moon - Colorado School of Public Health
Dana Dabelea - University of Colorado Anschutz Medical Campus
Katerina Kechris - University of Colorado Anschutz Medical Campus
Wei Perng - Colorado School of Public Health
Resource Type: Journal article
Publication Details: Pediatric obesity, Vol.19(12), pp.e13172-n/a
DOI: 10.1111/ijpo.13172
PMID: 39327854
PMCID: PMC11560695
NLM abbreviation: Pediatr Obes
ISSN: 2047-6302
eISSN: 2047-6310
Publisher: Wiley
Number of pages: 6
Grant note: UH3OD023248; ADA-7-22-ICTSPM-08; U01 DK134981; R01HL1281570 / The Healthy Start
Language: English
Date published: 12/01/2024
Academic Unit: Biostatistics; Internal Medicine
Record Identifier: 9984914017002771

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