Journal article
The presence of a cartilage-like proteoglycan in the adult human meniscus
Biochemical journal, Vol.197(1), pp.77-83
07/01/1981
DOI: 10.1042/bj1970077
PMCID: PMC1163056
PMID: 6895594
Abstract
Proteoglycans were extracted from the adult human meniscus under dissociative conditions and purified by CsCl-density-gradient centrifugation. The preparations of highest density contained proteoglycan that possessed the ability to interact with hyaluronic acid, was of large subunit size and was composed of chondroitin sulphate, keratan sulphate and sialic acid-containing oligosaccharides. This 'cartilage-like' proteoglycan also exhibited subunit and aggregate structures analogous to those of hyaline-cartilage proteoglycans when examined by electron microscopy. However, the composition of this proteoglycan was more comparable with proteoglycans from immature cartilage than from age-matched cartilage. The preparations from lower density, which were enriched in dermatan sulphate, contained smaller proteoglycan that was not able to interact with hyaluronic acid. This non-aggregating proteoglycan may be structurally distinct from the 'cartilage-like' proteoglycan, which does not contain dermatan sulphate.
Details
- Title: Subtitle
- The presence of a cartilage-like proteoglycan in the adult human meniscus
- Creators
- P J RoughleyD McNicolV SanterJ Buckwalter
- Resource Type
- Journal article
- Publication Details
- Biochemical journal, Vol.197(1), pp.77-83
- DOI
- 10.1042/bj1970077
- PMID
- 6895594
- PMCID
- PMC1163056
- NLM abbreviation
- Biochem J
- ISSN
- 0264-6021
- eISSN
- 1470-8728
- Publisher
- England
- Language
- English
- Date published
- 07/01/1981
- Academic Unit
- Stead Family Department of Pediatrics; Orthopedics and Rehabilitation; Injury Prevention Research Center
- Record Identifier
- 9984040494502771
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