Journal article
The prevalence of mitochondrial mutations associated with aminoglycoside-induced sensorineural hearing loss in an NICU population
The Laryngoscope, Vol.121(6), pp.1184-1186
06/2011
DOI: 10.1002/lary.21778
PMID: 21495045
Abstract
Several mitochondrial DNA variants increase risk for developing sensorineural hearing loss following exposure to aminoglycoside antibiotics, a particular concern in the premature infant population, as many of these babies spend time in neonatal intensive care units and are treated with aminoglycosides. To determine the relative prevalence of five mitochondrial DNA variants in the 12S rRNA gene, MT-RNR1, we genotyped 703 neonatal intensive care unit patients and 1473 individuals from the general Iowa population. We found that the aggregate frequency of these variants (∼1.8%) was comparable between populations. Although no hearing loss was detected by newborn hearing screens in the at-risk patients, these neonatal intensive care unit graduates have an increased life-time risk for developing aminoglycoside-induced deafness.
Details
- Title: Subtitle
- The prevalence of mitochondrial mutations associated with aminoglycoside-induced sensorineural hearing loss in an NICU population
- Creators
- Megan Ealy - Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology, University of Iowa, Iowa City, Iowa 52242, USAKatherine A LynchNicole C MeyerRichard J H Smith
- Resource Type
- Journal article
- Publication Details
- The Laryngoscope, Vol.121(6), pp.1184-1186
- DOI
- 10.1002/lary.21778
- PMID
- 21495045
- NLM abbreviation
- Laryngoscope
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- Publisher
- United States
- Language
- English
- Date published
- 06/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006408102771
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