The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells

Catherine J. Libby; Anh Nhat Tran; Sarah E. Scott; Corinne Griguer; Anita B. Hjelmeland

doi:10.1016/j.bbcan.2018.01.004

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The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells

Journal article

Open access

Peer reviewed

The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells

Catherine J. Libby, Anh Nhat Tran, Sarah E. Scott, Corinne Griguer and Anita B. Hjelmeland

Biochimica et biophysica acta. Reviews on cancer, Vol.1869(2), pp.175-188

04/2018

DOI: 10.1016/j.bbcan.2018.01.004

PMCID: PMC6596418

PMID: 29378228

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Abstract

De-regulated cellular energetics is an emerging hallmark of cancer with alterations to glycolysis, oxidative phosphorylation, the pentose phosphate pathway, lipid oxidation and synthesis and amino acid metabolism. Understanding and targeting of metabolic reprogramming in cancers may yield new treatment options, but metabolic heterogeneity and plasticity complicate this strategy. One highly heterogeneous cancer for which current treatments ultimately fail is the deadly brain tumor glioblastoma. Therapeutic resistance, within glioblastoma and other solid tumors, is thought to be linked to subsets of tumor initiating cells, also known as cancer stem cells. Recent profiling of glioblastoma and brain tumor initiating cells reveals changes in metabolism, as compiled here, that may be more broadly applicable. We will summarize the profound role for metabolism in tumor progression and therapeutic resistance and discuss current approaches to target glioma metabolism to improve standard of care.

Cancer stem cell

Glioblastoma

Metabolism

Novel therapeutics

Therapeutic resistance

Tumor initiating cell

Details

Title: Subtitle: The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells
Creators: Catherine J. Libby - University of Alabama at Birmingham
Anh Nhat Tran - University of Alabama at Birmingham
Sarah E. Scott - University of Alabama at Birmingham
Corinne Griguer - University of Alabama at Birmingham
Anita B. Hjelmeland - University of Alabama at Birmingham
Resource Type: Journal article
Publication Details: Biochimica et biophysica acta. Reviews on cancer, Vol.1869(2), pp.175-188
DOI: 10.1016/j.bbcan.2018.01.004
PMID: 29378228
PMCID: PMC6596418
NLM abbreviation: Biochim Biophys Acta Rev Cancer
ISSN: 0304-419X
eISSN: 1879-2561
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: R21NS096531; DOI: 10.13039/100011531, name: University of Alabama, award: R21NS096531
Language: English
Date published: 04/2018
Academic Unit: Radiation Oncology
Record Identifier: 9984312982202771

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