Journal article
The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies
Movement disorders, Vol.32(5), pp.726-738
05/2017
DOI: 10.1002/mds.26964
PMID: 28370517
Abstract
Asymptomatic, nonmanifesting carriers of leucine-rich repeat kinase 2 mutations are at increased risk of developing PD. Clinical and neuroimaging features may be associated with gene carriage and/or may demarcate individuals at greater risk for phenoconversion to PD.
To investigate clinical and dopamine transporter single-photon emission computed tomography imaging characteristics of leucine-rich repeat kinase 2 asymptomatic carriers.
A total of 342 carriers' and 259 noncarriers' relatives of G2019S leucine-rich repeat kinase 2/PD patients and 39 carriers' and 31 noncarriers' relatives of R1441G leucine-rich repeat kinase 2/PD patients were evaluated. Motor and nonmotor symptoms were assessed using specific scales and questionnaires. Neuroimaging quantitative data were obtained in 81 carriers and compared with 41 noncarriers.
G2019S carriers scored higher in motor scores and had lower radioligand uptake compared to noncarriers, but no differences in nonmotor symptoms scores were observed. R1441G carriers scored higher in motor scores, had lower radioligand uptake, and had higher scores in depression, dysautonomia, and Rapid Eye Movements Sleep Behavior Disorder Screening Questionnaire scores, but had better cognition scores than noncarriers. Among G2019S carriers, a group with "mild motor signs" was identified, and was significantly older, with worse olfaction and lower radioligand uptake.
G2019S and R1441G carriers differ from their noncarriers' relatives in higher motor scores and slightly lower radioligand uptake. Nonmotor symptoms were mild, and different nonmotor profiles were observed in G2019S carriers compared to R1441G carriers. A group of G2019S carriers with known prodromal features was identified. Longitudinal studies are required to determine whether such individuals are at short-term risk of developing overt parkinsonism. © 2017 International Parkinson and Movement Disorder Society.
Details
- Title: Subtitle
- The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies
- Creators
- Claustre Pont-Sunyer - Neurology Unit, Hospital General de Granollers, Universitat Internacional de Catalunya, Granollers, SpainEduardo Tolosa - Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainChelsea Caspell-Garcia - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USAChristopher Coffey - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USARoy N Alcalay - Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USAPiu Chan - Departments of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, ChinaJohn E Duda - Parkinson's Disease Research, Education and Clinical Center, Michael J. Crescenz VA Medical Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USAMaurizio Facheris - The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USARubén Fernández-Santiago - Laboratory of Neurodegenerative Disorders, Department of Neurology, Hospital Clínic of Barcelona, Institutd'InvestigacionsBiomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, and the Centre for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, SpainKenneth Marek - Institute for Neurodegenerative Disorders and Molecular NeuroImaging, New Haven, Connecticut, USAFrancisco Lomeña - Department of Nuclear Medicine, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, SpainConnie Marras - Toronto Western Hospital Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, University of Toronto, Toronto, Ontario, CanadaElisabet Mondragon - Department of Neurology, Movement Disorders Unit. Hospital Universitario Donostia. Biodonostia Research Institute, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), San Sebastián, Guipúzcoa, SpainRachel Saunders-Pullman - Department of Neurology, Mount Sinai Beth Israel Medical Center and Icahn School of Medicine at Mount Sinai, New York, New York, USABjorg Waro - Department of Neurology, Norwegian University of Science and Technology, Trondheim, NorwayLRRK2 Cohort Consortium
- Resource Type
- Journal article
- Publication Details
- Movement disorders, Vol.32(5), pp.726-738
- Publisher
- United States
- DOI
- 10.1002/mds.26964
- PMID
- 28370517
- ISSN
- 0885-3185
- eISSN
- 1531-8257
- Grant note
- DOI: 10.13039/100000864, name: Michael J. Fox Foundation for Parkinson's Research
- Language
- English
- Date published
- 05/2017
- Academic Unit
- Biostatistics
- Record Identifier
- 9983997316702771
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