Journal article
The prognostic impact of level I lymph node involvement in oropharyngeal squamous cell carcinoma
Head & neck, Vol.41(11), pp.3895-3905
11/01/2019
DOI: 10.1002/hed.25927
PMID: 31468644
Abstract
Background We investigated the impact of level I lymph node involvement (LNI) on survival for patients with oropharyngeal squamous cell carcinoma (OPSCC). Methods We performed a cohort study of patients with OPSCC who underwent resection with known human papillomavirus (HPV) status in the National Cancer Database (2010-2014). Results Among 5591 patients with OPSCC, 599 (10.7%) had level I LNI. Predictors of level I LNI included pT classification (pT3 vs pT1; odds ratio [OR], 1.95; P < 0.001), pN classification (pN3 vs pN1; OR, 1.63; P = 0.05), and level III LNI (OR, 6.05; P < 0.001). Among included patients, 4035 had known survival status. Level I LNI predicted inferior overall survival (OS) while adjusting for covariates (HR, 1.64; P < 0.001). Subset analyses revealed association between level I LNI and inferior OS among patients with base of tongue cancer, pT/pN classification greater than 1, and HPV-negative cancer. Conclusions Level I LNI predicts inferior OS, particular among patients with at least pT2 or pN2 OPSCC.
Details
- Title: Subtitle
- The prognostic impact of level I lymph node involvement in oropharyngeal squamous cell carcinoma
- Creators
- Roy Xiao - Harvard UniversityMatthew C. Ward - Southeast Radiation Oncology GroupKailin Yang - Cleveland ClinicDavid J. Adelstein - Cleveland ClinicShlomo A. Koyfman - Cleveland ClinicBrandon L. Prendes - Cleveland ClinicBrian B. Burkey - Cleveland Clinic
- Resource Type
- Journal article
- Publication Details
- Head & neck, Vol.41(11), pp.3895-3905
- Publisher
- Wiley
- DOI
- 10.1002/hed.25927
- PMID
- 31468644
- ISSN
- 1043-3074
- eISSN
- 1097-0347
- Number of pages
- 11
- Language
- English
- Date published
- 11/01/2019
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984696710102771
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