Journal article
The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels
Journal of the American Geriatrics Society (JAGS), Vol.48(11), pp.1404-1407
2000
DOI: 10.1111/j.1532-5415.2000.tb02629.x
PMID: 11083315
Abstract
OBJECTIVE: We sought to determine the prognostic value of serum albumin for 4-year mortality among high-functioning persons who did or did not have evidence of inflammation as indicated by high interleukin-6 (IL-6) levels. DESIGN: We used a case-cohort design of healthy, nondisabled older persons who had serum albumin and plasma IL-6 measured at baseline. Crude and multiply adjusted (for sociodemographics and chronic diseases) proportional hazards models were used to identify the effect of baseline levels of serum albumin level on 4-year mortality among those with higher and lower levels of IL-6. RESULTS: Among subjects without evidence of IL-6-mediated inflammation (IL-6 < 3.20 pg/mL), having a lower (≤ 4.4 g/dL) albumin level was associated with a multiply adjusted relative risk of 2.1 for 4-year mortality compared with those wish higher albumin. In the presence of inflammation (IL-6 ≥ 3.20 pg/mL), higher and lower serum albumin levels had similar risks (adjusted relative risks 4.0 and 3.8, respectively) compared with the referent group (higher albumin and low IL-6). CONCLUSIONS: High serum albumin has a protective effect in healthy older persons who do not have evidence of cytokine-mediated inflammation. This protective effect is not conferred in presence of inflammation. The mechanisms by which inflammation eliminates the protective effect of high albumin remain to be determined.
Details
- Title: Subtitle
- The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels
- Creators
- David B Reuben - University of California, Los AngelesLuigi Ferrucci - Florence (Netherlands)Robert Wallace - University of IowaRussell P Tracy - University of VermontM. Chiara Corti - University of Padova, Padova, ItalyHarley Heimovitz - Sytel, Bethesda, MarylandTamara B Harris - National Institute on Aging
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.48(11), pp.1404-1407
- DOI
- 10.1111/j.1532-5415.2000.tb02629.x
- PMID
- 11083315
- NLM abbreviation
- J Am Geriatr Soc
- ISSN
- 0002-8614
- eISSN
- 1532-5415
- Publisher
- Blackwell
- Language
- English
- Date published
- 2000
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363613302771
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