Journal article
The quest for restoring hearing: Understanding ear development more completely
BioEssays, Vol.37(9), pp.1016-1027
09/2015
DOI: 10.1002/bies.201500044
PMCID: PMC4710855
PMID: 26208302
Abstract
Neurosensory hearing loss is a growing problem of super-aged societies. Cochlear implants can restore some hearing, but rebuilding a lost hearing organ would be superior. Research has discovered many cellular and molecular steps to develop a hearing organ but translating those insights into hearing organ restoration remains unclear. For example, we cannot make various hair cell types and arrange them into their specific patterns surrounded by the right type of supporting cells in the right numbers. Our overview of the topologically highly organized and functionally diversified cellular mosaic of the mammalian hearing organ highlights what is known and unknown about its development. Following this analysis, we suggest critical steps to guide future attempts toward restoration of a functional organ of Corti. We argue that generating mutant mouse lines that mimic human pathology to fine-tune attempts toward long-term functional restoration are needed to go beyond the hope generated by restoring single hair cells in postnatal sensory epithelia.
Details
- Title: Subtitle
- The quest for restoring hearing: Understanding ear development more completely
- Creators
- Israt Jahan - Department of Biology, CLAS, University of Iowa, Iowa City, IA, USANing Pan - Department of Biology, CLAS, University of Iowa, Iowa City, IA, USAKaren L Elliott - Department of Biology, CLAS, University of Iowa, Iowa City, IA, USABernd Fritzsch - Department of Biology, CLAS, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- BioEssays, Vol.37(9), pp.1016-1027
- DOI
- 10.1002/bies.201500044
- PMID
- 26208302
- PMCID
- PMC4710855
- NLM abbreviation
- Bioessays
- ISSN
- 0265-9247
- eISSN
- 1521-1878
- Publisher
- United States
- Grant note
- R03 DC013655 / NIDCD NIH HHS R03DC013655 / NIDCD NIH HHS R01 DC005590 / NIDCD NIH HHS P30 DC010362 / NIDCD NIH HHS
- Language
- English
- Date published
- 09/2015
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070429102771
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