Journal article
The regulation of T follicular helper responses during infection
Current opinion in immunology, Vol.34, pp.68-74
06/2015
DOI: 10.1016/j.coi.2015.02.007
PMCID: PMC4444382
PMID: 25726751
Abstract
Following infection, naïve CD4 T cells can differentiate into various functionally distinct effector and memory subsets, including T follicular helper (TFH) cells that orchestrate germinal center (GC) reactions necessary for high-affinity, pathogen-specific antibody responses. The origins and function of this cell type have been extensively examined in response to subunit immunization with model antigens. More recently, we are beginning to also appreciate the extent to which microbial infections shape the generation, function and maintenance of TFH cells. Here, we review recent advances and highlight additional knowledge gaps in our understanding of how microbial infections influence priming, differentiation, localization and activity of TFH cells following acute and chronic infections.
Details
- Title: Subtitle
- The regulation of T follicular helper responses during infection
- Creators
- Noah S Butler - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA. Electronic address: noah-butler@ouhsc.eduDivine I Kulu - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in immunology, Vol.34, pp.68-74
- DOI
- 10.1016/j.coi.2015.02.007
- PMID
- 25726751
- PMCID
- PMC4444382
- NLM abbreviation
- Curr Opin Immunol
- ISSN
- 0952-7915
- eISSN
- 1879-0372
- Publisher
- England
- Grant note
- 1K22AI099070 / NIAID NIH HHS K22 AI099070 / NIAID NIH HHS P20 RR016478 / NCRR NIH HHS P20 GM103447 / NIGMS NIH HHS 8P20GM103447 / NIGMS NIH HHS
- Language
- English
- Date published
- 06/2015
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001217302771
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