Journal article
The relation of peripheral and central sensitization to muscle co-contraction: the MOST study
Osteoarthritis and cartilage, Vol.28(9), pp.1214-1219
09/2020
DOI: 10.1016/j.joca.2020.06.002
PMCID: PMC7727285
PMID: 32585174
Abstract
To examine the relation of pain sensitization to altered motor activity in knee OA as assessed by hamstrings muscle co-contraction during maximal effort knee extension.
Medial, lateral, and overall hamstring co-contraction was assessed in the Multicenter Osteoarthritis (MOST) Study cohort using electromyography during isokinetic knee extension at 60°/second. Mechanical temporal summation of pain (TS) was assessed at the right wrist and pressure pain thresholds (PPT) were assessed at the patellae; PPTs were categorized into sex-specific tertiles. Muscle co-contraction was categorized into age- and sex-specific tertiles. We evaluated the relation of measures of sensitization to muscle co-contraction using a generalized logistic regression model.
1633 participants were included: mean age and BMI was 67.3 ± 7.7 years and 30.3 ± 5.6 kg/m
, respectively; 58% were female. Presence of TS was associated with higher overall (OR 1.3, 95% confidence interval (CI) (1.0-1.8)), medial (1.4 (1.0-1.9), and lateral (1.3 (1.0, 1.9)) hamstring co-contraction. The lowest PPT tertile (greater sensitivity) was associated with higher overall (1.5 (1.0, 2.3)) and medial (1.5 (1.0, 2.3)) hamstring co-contraction compared with those in the highest PPT tertile.
Greater pain sensitization, as assessed by presence of TS at the wrist and low patellar PPT, was associated with greater overall and medial hamstring co-contraction during knee extension. This provides support to the possibility that peripheral and/or central nervous system alterations may not only affect pain sensitivity, but also motor function.
Details
- Title: Subtitle
- The relation of peripheral and central sensitization to muscle co-contraction: the MOST study
- Creators
- J J Stefanik - Boston UniversityL Frey-Law - University of IowaN A Segal - University of Kansas Medical CenterJ Niu - Baylor College of MedicineC E Lewis - University of Alabama at BirminghamM C Nevitt - University of California, San FranciscoT Neogi - Boston University
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.28(9), pp.1214-1219
- DOI
- 10.1016/j.joca.2020.06.002
- PMID
- 32585174
- PMCID
- PMC7727285
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS K24 AR070892 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS R01 AR062506 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS K23 AR070913 / NIAMS NIH HHS
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Epidemiology; Nursing; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984295048802771
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