Journal article
The relationship between DNA methylation in neurotrophic genes and age as evidenced from three independent cohorts: differences by delirium status
Neurobiology of aging, Vol.94, pp.227-235
10/2020
DOI: 10.1016/j.neurobiolaging.2020.06.003
PMID: 32650186
Abstract
We previously reported the association between DNA methylation (DNAm) of pro-inflammatory cytokine genes and age. In addition, neurotrophic factors are known to be associated with age and neurocognitive disorders. Therefore, we hypothesized that DNAm of neurotrophic genes change with age, especially in delirium patients. DNAm was analyzed using the Illumina HumanMethylation450 or HumanMethylationEPIC BeadChip Kit in 3 independent cohorts: blood from 383 Grady Trauma Project subjects, brain from 21 neurosurgery patients, and blood from 87 inpatients with and without delirium. Both blood and brain samples showed that most of the DNAm of neurotrophic genes were positively correlated with age. Furthermore, DNAm of neurotrophic genes was more positively correlated with age in delirium cases than in non-delirium controls. These findings support our hypothesis that the neurotrophic genes may be epigenetically modulated with age, and this process may be contributing to the pathophysiology of delirium.
•Neurotrophic genes' DNAm were positively correlated with age in blood and brain.•Neurotrophic genes' DNAm were positively correlated with age in delirious patients.•Neurotrophic genes may be modulated with aging epigenetically.
Details
- Title: Subtitle
- The relationship between DNA methylation in neurotrophic genes and age as evidenced from three independent cohorts: differences by delirium status
- Creators
- Taku Saito - Department of Psychiatry, University of Iowa, Iowa City, IA, USAPatricia R Braun - Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, USASophia Daniel - Department of Psychiatry, University of Iowa, Iowa City, IA, USASydney S Jellison - Department of Psychiatry, University of Iowa, Iowa City, IA, USAMandy Hellman - Department of Psychiatry, University of Iowa, Iowa City, IA, USAEri Shinozaki - Department of Internal Medicine, University of Iowa, Iowa City, IA, USASangil Lee - Department of Emergency Medicine, University of Iowa, Iowa City, IA, USAHyunkeun R Cho - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, USAAihide Yoshino - Department of Psychiatry, School of Medicine, National Defense Medical College, Tokorozawa, Saitama, JapanHiroyuki Toda - Department of Psychiatry, School of Medicine, National Defense Medical College, Tokorozawa, Saitama, JapanGen Shinozaki - Department of Psychiatry, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Neurobiology of aging, Vol.94, pp.227-235
- DOI
- 10.1016/j.neurobiolaging.2020.06.003
- PMID
- 32650186
- NLM abbreviation
- Neurobiol Aging
- ISSN
- 0197-4580
- eISSN
- 1558-1497
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000025, name: National Institute of Mental Health; DOI: 10.13039/100000001, name: National Science Foundation
- Language
- English
- Date published
- 10/2020
- Academic Unit
- Psychiatry; Emergency Medicine; Iowa Neuroscience Institute; Biostatistics; Anesthesia; Injury Prevention Research Center; General Internal Medicine; Neurosurgery; Otolaryngology; Internal Medicine
- Record Identifier
- 9984070949502771
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