The relationship between quadriceps muscle weakness and worsening of knee pain in the MOST cohort: a 5-year longitudinal study

N.A Glass; J.C Torner; L.A Frey Law; K Wang; T Yang; M.C Nevitt; D.T Felson; C.E Lewis; N.A Segal

doi:10.1016/j.joca.2013.05.016

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The relationship between quadriceps muscle weakness and worsening of knee pain in the MOST cohort: a 5-year longitudinal study

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The relationship between quadriceps muscle weakness and worsening of knee pain in the MOST cohort: a 5-year longitudinal study

N.A Glass, J.C Torner, L.A Frey Law, K Wang, T Yang, M.C Nevitt, D.T Felson, C.E Lewis and N.A Segal

Osteoarthritis and cartilage, Vol.21(9), pp.1154-1159

09/2013

DOI: 10.1016/j.joca.2013.05.016

PMCID: PMC3774035

PMID: 23973125

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Abstract

To determine whether quadriceps weakness is associated with elevated risk of worsening knee pain over 5 years. The Multicenter Osteoarthritis Study (MOST) is a longitudinal study of 50–79-year-old adults with knee osteoarthritis (OA) or known risk factors for knee OA. The predictor variable was baseline isokinetic quadriceps strength. Covariates included baseline body mass index (BMI), physical activity level, and history of knee surgery. The outcome was worsening pain reported on the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index pain subscale or knee replacement surgery between baseline and 5-year follow-up. Analyses were knee-based and used generalized estimating equations, stratified by sex to assess whether the lowest compared with the highest tertile of baseline quadriceps strength was associated with an increased risk of worsening knee pain at 5-year follow-up, controlling for age, BMI, history of knee surgery, and physical activity level as well as correlation between knees within participants. Analyses of worsening knee pain included 4,648 knees from 2,404 participants (61% female). Men with lower quadriceps strength did not have a higher risk of worsening knee pain (RR {95% CI} = 1.01 {0.78–1.32}, P = 0.9183). However, women in the lowest compared with the highest strength tertile had a 28% increased risk of worsening knee pain (RR {95% CI} = 1.28 {1.08–1.52}, P = 0.0052). Quadriceps weakness was associated with an increased risk of worsening of knee pain over 5 years in women, but not in men.

Knee pain

Quadriceps weakness

Knee osteoarthritis

Details

Title: Subtitle: The relationship between quadriceps muscle weakness and worsening of knee pain in the MOST cohort: a 5-year longitudinal study
Creators: N.A Glass - Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA, USA
J.C Torner - Department of Epidemiology, The University of Iowa, Iowa City, IA, USA
L.A Frey Law - Department of Physical Therapy and Rehabilitation Science, The University of Iowa, Iowa City, IA, USA
K Wang - Boston University
T Yang - Boston University, Boston, MA, USA
M.C Nevitt - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
D.T Felson - Clinical Epidemiology and Training Unit, Boston University, Boston, MA, USA
C.E Lewis - Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
N.A Segal - Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Osteoarthritis and cartilage, Vol.21(9), pp.1154-1159
DOI: 10.1016/j.joca.2013.05.016
PMID: 23973125
PMCID: PMC3774035
NLM abbreviation: Osteoarthritis Cartilage
ISSN: 1063-4584
eISSN: 1522-9653
Publisher: Elsevier Ltd
Language: English
Date published: 09/2013
Academic Unit: Epidemiology; Orthopedics and Rehabilitation; Surgery; Nursing; Physical Therapy and Rehabilitation Science; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983996090902771

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