The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome

Maret G Traber; Garry R Buettner; Richard S Bruno

doi:10.1016/j.redox.2018.101091

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The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome

Journal article

Open access

Peer reviewed

The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome

Maret G Traber, Garry R Buettner and Richard S Bruno

Redox biology, Vol.21, pp.101091-101091

02/2019

DOI: 10.1016/j.redox.2018.101091

PMCID: PMC6327911

PMID: 30640128

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Abstract

Metabolic syndrome (MetS) is a constellation of cardiometabolic risk factors, which together predict increased risk of more serious chronic diseases. We propose that one consequence of dietary overnutrition is increased abundance of Gram-negative bacteria in the gut that cause increased inflammation, impaired gut function, and endotoxemia that further dysregulate the already compromised antioxidant vitamin status in MetS. This discussion is timely because "healthy" individuals are no longer the societal norm and specialized dietary requirements are needed for the growing prevalence of MetS. Further, these lines of evidence provide the foundational basis for investigation that poor vitamin C status promotes endotoxemia, leading to metabolic dysfunction that impairs vitamin E trafficking through a mechanism involving the gut-liver axis. This report will establish a critical need for translational research aimed at validating therapeutic approaches to manage endotoxemia-an early, but inflammation-inducing phenomenon, which not only occurs in MetS, but is also prognostic of more advanced metabolic disorders including type 2 diabetes mellitus, as well as the increasing severity of nonalcoholic fatty liver diseases.

Metabolic Syndrome - etiology

Prevalence

Oxidation-Reduction

Oxidative Stress

Antioxidants - metabolism

Humans

Liver - metabolism

Oxidants - metabolism

Metabolic Syndrome - metabolism

Endotoxemia - etiology

Gastrointestinal Tract - metabolism

Ascorbic Acid - metabolism

Animals

Metabolic Syndrome - diagnosis

Vitamin E - metabolism

Endotoxemia - metabolism

Metabolic Syndrome - epidemiology

Details

Title: Subtitle: The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome
Creators: Maret G Traber - Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Garry R Buettner - Free Radical & Radiation Biology Program, The University of Iowa, Iowa City, IA 52242, USA
Richard S Bruno - Human Nutrition Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: bruno.27@osu.edu
Resource Type: Journal article
Publication Details: Redox biology, Vol.21, pp.101091-101091
DOI: 10.1016/j.redox.2018.101091
PMID: 30640128
PMCID: PMC6327911
NLM abbreviation: Redox Biol
ISSN: 2213-2317
eISSN: 2213-2317
Publisher: Netherlands
Grant note: P30 ES005605 / NIEHS NIH HHS R01 DK081761 / NIDDK NIH HHS UL1 TR001070 / NCATS NIH HHS R01 CA169046 / NCI NIH HHS
Language: English
Date published: 02/2019
Academic Unit: Radiation Oncology
Record Identifier: 9984047753302771

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