Journal article
The relationship of 1,25-dihydroxyvitamin D and radial bone mass
Bone and mineral, Vol.10(2), pp.139-148
1990
DOI: 10.1016/0169-6009(90)90089-X
PMID: 2207393
Abstract
We assessed the association between radial bone mass and vitamin D considering age, estrogen sufficiency and thiazide use in 373 women, aged 20–80 years in a geographically defined area. We measured cortical bone mass of the radius, using photon absorptiometry, and serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, using preliminary chromatography and protein-binding assay.
We found that 1,25-dihydroxyvitamin D levels were higher in premenopausal women and postmenopausal women using estrogen replacement as compared to postmenopausal women (
P < 0.02). Users of thiazide-based antihypertensive medications had significantly lower 1,25-dihydroxyvitamin D than their age-matched peers (
P < 0.02). Dietary calcium intake was negatively associated with 1,25-dihydroxyvitamin D levels. Estimates of vitamin D intake from diet or sunlight were not associated with 1,25-dihydroxyvitamin D levels; nor were levels of 1,25-dihydroxyvitamin D related to 25-hydroxyvitamin D levels.
1,25-Dihydroxyvitamin D was negatively and significantly associated with radial bone mass, contributing approximately 6% of the explained variability of bone mass measurements. Together age, body size, thiazide use and 1,25-dihydroxyvitamin D accounted for about 47% of the explained variability in radial bone mass measurement. 1,25-Dihydroxyvitamin D was not associated with bone mass in women currently using a thiazide medication.
Details
- Title: Subtitle
- The relationship of 1,25-dihydroxyvitamin D and radial bone mass
- Creators
- MaryFran R. Sowers - University of MichiganRobert B. Wallace - University of IowaBruce W. Hollis - Medical University of South Carolina
- Resource Type
- Journal article
- Publication Details
- Bone and mineral, Vol.10(2), pp.139-148
- DOI
- 10.1016/0169-6009(90)90089-X
- PMID
- 2207393
- NLM abbreviation
- Bone Miner
- ISSN
- 0169-6009
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1990
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364421202771
Metrics
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