Journal article
The relationship of neurodevelopmental impairment to concurrent early childhood outcomes of extremely preterm infants
Journal of perinatology, Vol.41(9), pp.2270-2278
09/2021
DOI: 10.1038/s41372-021-00999-7
PMCID: PMC7985590
PMID: 33758389
Abstract
Determine how neurodevelopmental impairment (NDI) relates to concurrent outcomes for children born extremely preterm.
Retrospective cohort study children born 22 0/7-26 6/7 weeks' gestation at NICHD Neonatal Research Network hospitals. Outcomes were ascertained at 18-22 months' corrected age.
Of 6562 children, 2618 (40%) died and 441 (7%) had no follow-up. Among the remaining 3483 children, 825 (24%), 1576 (45%), 657 (19%), and 425 (12%) had no, potential/mild, moderate, and severe NDI, respectively. Rehospitalization, respiratory medications, surgery, and medical support services were associated with greater NDI severity but affected >10% of children without NDI. Rehospitalization occurred in 40% of children with no NDI (mean (SD): 1.7 (1.3) episodes).
Medical, functional, and social outcomes at 18-22 months' corrected age were associated with NDI; however, many children without NDI were affected. These data should contribute to counseling families and the design of studies for childhood outcomes beyond NDI.
Details
- Title: Subtitle
- The relationship of neurodevelopmental impairment to concurrent early childhood outcomes of extremely preterm infants
- Creators
- Matthew A Rysavy - University of IowaTarah T Colaizy - University of IowaCarla M Bann - RTI InternationalSara B DeMauro - University of PennsylvaniaAndrea F Duncan - University of PennsylvaniaJane E Brumbaugh - Mayo Clinic in FloridaMyriam Peralta-Carcelen - University of Alabama at BirminghamHeidi M Harmon - University of IowaKaren J Johnson - University of IowaSusan R Hintz - Stanford UniversityBetty R Vohr - Brown UniversityEdward F Bell - University of IowaEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.41(9), pp.2270-2278
- DOI
- 10.1038/s41372-021-00999-7
- PMID
- 33758389
- PMCID
- PMC7985590
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Grant note
- U10 HD053109 / NICHD NIH HHS F32HD098782 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD087226 / NICHD NIH HHS UL1 TR003167 / NCATS NIH HHS U10HD34216 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD027904 / NICHD NIH HHS U10 HD53109 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) U24 HD095254 / NICHD NIH HHS U10HD53109 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) U10HD27880 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) U10HD68244 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) U10 HD027904 / NICHD NIH HHS
- Language
- English
- Date published
- 09/2021
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354050502771
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