Journal article
The relationship of subcortical MRI hyperintensities and brain volume to cognitive function in vascular dementia
Journal of the International Neuropsychological Society, Vol.8(6), pp.743-752
09/2002
DOI: 10.1017/S1355617702860027
PMID: 12240738
Abstract
The relationship between MRI findings (i.e., subcortical
hyperintensities; SH, whole brain volume) and the cognitive
dysfunction of vascular dementia (VaD) was examined. Participants
included 24 persons that met NINDS-AIREN criteria for VaD (MMSE
= 19.9 ± 4.2) and underwent comprehensive neuropsychological
assessment and MRI brain imaging. The volume of subcortical
hyperintensities (SH) was strongly associated with
executive–psychomotor performance, but not with performance
across other cognitive domains or global cognitive functional
level. Conversely, WBV was strongly associated with global
cognitive functioning and performance across most cognitive
domains (memory, language, visual integration), but not with
executive–psychomotor functioning. The failure of SH to
account for either the global dementia evident in these VaD
patients or impairments across most cognitive domains suggests
that deep subcortical white matter disease may only indirectly
contribute to the global cognitive dysfunction of VaD. That
WBV emerged as a stronger correlate of dementia raises further
questions regarding the cerebral mechanisms that contribute
to the development of VaD. (JINS, 2002, 8,
743–752.)
Details
- Title: Subtitle
- The relationship of subcortical MRI hyperintensities and brain volume to cognitive function in vascular dementia
- Creators
- RONALD A COHEN - Department of Psychiatry, Brown Medical School, Providence, Rhode IslandROBERT H PAUL - Department of Psychiatry, Brown Medical School, Providence, Rhode IslandBRIAN R OTT - Department of Neurology, Brown Medical School, Providence, Rhode IslandDAVID J MOSER - Department of Psychiatry, University of Iowa, College of Medicine, Iowa CityTRICIA M ZAWACKI - Department of Psychiatry, Brown Medical School, Providence, Rhode IslandWILLIAM STONE - Department of Neurology, Brown Medical School, Providence, Rhode IslandNORMAN GORDON - Department of Neurology, Brown Medical School, Providence, Rhode Island
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.8(6), pp.743-752
- Publisher
- Cambridge University Press; New York, USA
- DOI
- 10.1017/S1355617702860027
- PMID
- 12240738
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Number of pages
- 10
- Language
- English
- Date published
- 09/2002
- Academic Unit
- Psychiatry; Medicine Administration
- Record Identifier
- 9984003900602771
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