The repeatability of mean defect with size III and size V standard automated perimetry

Michael Wall; Carrie K Doyle; K D Zamba; Paul Artes; Chris A Johnson

doi:10.1167/iovs.12-10299

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The repeatability of mean defect with size III and size V standard automated perimetry

Journal article

Open access

Peer reviewed

The repeatability of mean defect with size III and size V standard automated perimetry

Michael Wall, Carrie K Doyle, K D Zamba, Paul Artes and Chris A Johnson

Investigative ophthalmology & visual science, Vol.54(2), pp.1345-1351

02/15/2013

DOI: 10.1167/iovs.12-10299

PMID: 23341012

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Abstract

The mean defect (MD) of the visual field is a global statistical index used to monitor overall visual field change over time. Our goal was to investigate the relationship of MD and its variability for two clinically used strategies (Swedish Interactive Threshold Algorithm [SITA] standard size III and full threshold size V) in glaucoma patients and controls. We tested one eye, at random, for 46 glaucoma patients and 28 ocularly healthy subjects with Humphrey program 24-2 SITA standard for size III and full threshold for size V each five times over a 5-week period. The standard deviation of MD was regressed against the MD for the five repeated tests, and quantile regression was used to show the relationship of variability and MD. A Wilcoxon test was used to compare the standard deviations of the two testing methods following quantile regression. Both types of regression analysis showed increasing variability with increasing visual field damage. Quantile regression showed modestly smaller MD confidence limits. There was a 15% decrease in SD with size V in glaucoma patients (P = 0.10) and a 12% decrease in ocularly healthy subjects (P = 0.08). The repeatability of size V MD appears to be slightly better than size III SITA testing. When using MD to determine visual field progression, a change of 1.5 to 4 decibels (dB) is needed to be outside the normal 95% confidence limits, depending on the size of the stimulus and the amount of visual field damage.

Visual Field Tests - methods

Visual Fields - physiology

Scotoma - diagnosis

Follow-Up Studies

Sensory Thresholds

Humans

Middle Aged

Male

Glaucoma - diagnosis

Scotoma - etiology

Scotoma - physiopathology

Adult

Female

Aged

Glaucoma - physiopathology

Details

Title: Subtitle: The repeatability of mean defect with size III and size V standard automated perimetry
Creators: Michael Wall - Department of Ophthalmology, University of Iowa,College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242-1053, USA. michael-wall@uiowa.edu
Carrie K Doyle
K D Zamba
Paul Artes
Chris A Johnson
Resource Type: Journal article
Publication Details: Investigative ophthalmology & visual science, Vol.54(2), pp.1345-1351
DOI: 10.1167/iovs.12-10299
PMID: 23341012
NLM abbreviation: Invest Ophthalmol Vis Sci
ISSN: 0146-0404
eISSN: 1552-5783
Publisher: United States
Language: English
Date published: 02/15/2013
Academic Unit: Neurology; Radiology; Biostatistics; Ophthalmology and Visual Sciences
Record Identifier: 9983980048202771

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