The repetitive muscular action potential in neuromuscular transmission disorders due to acetylcholinesterase inhibition

R Besser; U Dillmann; L Gutmann; H C Hopf

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Journal article

The repetitive muscular action potential in neuromuscular transmission disorders due to acetylcholinesterase inhibition

R Besser, U Dillmann, L Gutmann and H C Hopf

EEG-EMG, Vol.19(2), pp.85-91

06/1988

PMID: 2841086

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Abstract

Neuromuscular transmission was studied in 11 patients with organophosphate intoxication. The compound muscle action potential (MAP) was recorded from the thumb after single, repetitive (1-50 Hz) and paired stimulation. All patients showed a prolonged MAP. The duration increased with the severity of intoxication. The number of peaks varied only slightly. In all cases repetitive stimulation reduced the later components of the MAP. There was no correlation with tetanic fade of the initial negative component. One patient had a pronounced tetanic fade but a slight reduction of repetitive components. In view of experimental studies a combined pre- and postsynaptic effect seems to be responsible.

Parathion - poisoning

Neuromuscular Diseases - chemically induced

Neuromuscular Junction - drug effects

Humans

Middle Aged

Muscles - physiopathology

Organophosphorus Compounds

Dimethoate - poisoning

Neuromuscular Junction - physiopathology

Neuromuscular Diseases - physiopathology

Suicide, Attempted

Muscles - drug effects

Cholinesterase Inhibitors - poisoning

Adult

Organothiophosphates

Synaptic Transmission - drug effects

Aged

Insecticides - poisoning

Organophosphate Poisoning

Action Potentials - drug effects

Details

Title: Subtitle: The repetitive muscular action potential in neuromuscular transmission disorders due to acetylcholinesterase inhibition
Creators: R Besser - Neurologische Universitätsklinik Mainz
U Dillmann
L Gutmann
H C Hopf
Resource Type: Journal article
Publication Details: EEG-EMG, Vol.19(2), pp.85-91
Publisher: Germany
PMID: 2841086
ISSN: 0012-7590
Alternative title: Das repetitive Muskelantwortpotential bei neuromuskulärer Ubertragungsstörung durch Hemmung der Azetylcholinesterase
Language: German
Date published: 06/1988
Academic Unit: Neurology
Record Identifier: 9984020731202771

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