The rise of cell therapy trials for stroke: review of published and registered studies

Paulo Henrique Rosado-de-Castro; Pedro Moreno Pimentel-Coelho; Lea Mirian Barbosa da Fonseca; Gabriel Rodriguez de Freitas; Rosalia Mendez-Otero

doi:10.1089/scd.2013.0089

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The rise of cell therapy trials for stroke: review of published and registered studies

Journal article

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The rise of cell therapy trials for stroke: review of published and registered studies

Paulo Henrique Rosado-de-Castro, Pedro Moreno Pimentel-Coelho, Lea Mirian Barbosa da Fonseca, Gabriel Rodriguez de Freitas and Rosalia Mendez-Otero

Stem cells and development, Vol.22(15), pp.2095-2111

08/01/2013

DOI: 10.1089/scd.2013.0089

PMCID: PMC3715770

PMID: 23509917

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Abstract

Stroke is the second leading cause of death and the third leading cause of disability worldwide. Approximately 16 million first-ever strokes occur each year, leading to nearly 6 million deaths. Nevertheless, currently, very few therapeutic options are available. Cell therapies have been applied successfully in different hematological diseases, and are currently being investigated for treating ischemic heart disease, with promising results. Recent preclinical studies have indicated that cell therapies may provide structural and functional benefits after stroke. However, the effects of these treatments are not yet fully understood and are the subject of continuing investigation. Meanwhile, different clinical trials for stroke, the majority of them small, nonrandomized, and uncontrolled, have been reported, and their results indicate that cell therapy seems safe and feasible in these conditions. In the last 2 years, the number of published and registered trials has dramatically increased. Here, we review the main findings available in the field, with emphasis on the clinical results. Moreover, we address some of the questions that have been raised to date, to improve future studies.

Animals

Bone Marrow Transplantation

Clinical Trials as Topic

Cord Blood Stem Cell Transplantation

Humans

Injections, Intra-Arterial

Injections, Intraventricular

Injections, Spinal

Mesenchymal Stem Cell Transplantation

Neural Stem Cells - physiology

Neural Stem Cells - transplantation

Stroke - therapy

Details

Title: Subtitle: The rise of cell therapy trials for stroke: review of published and registered studies
Creators: Paulo Henrique Rosado-de-Castro - Hospital Universitário Clementino Fraga Filho
Pedro Moreno Pimentel-Coelho - Universidade Federal do Rio de Janeiro
Lea Mirian Barbosa da Fonseca - Universidade Federal do Rio de Janeiro
Gabriel Rodriguez de Freitas - Universidade Federal do Rio de Janeiro
Rosalia Mendez-Otero - Universidade Federal do Rio de Janeiro
Resource Type: Journal article
Publication Details: Stem cells and development, Vol.22(15), pp.2095-2111
DOI: 10.1089/scd.2013.0089
PMID: 23509917
PMCID: PMC3715770
NLM abbreviation: Stem Cells Dev
ISSN: 1547-3287
eISSN: 1557-8534
Language: English
Date published: 08/01/2013
Academic Unit: Radiology
Record Identifier: 9985143554002771

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