The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination

G F Wu; A A Dandekar; L Pewe; S Perlman

doi:10.1007/978-1-4615-1325-4_51

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The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination

Journal article

Open access

Peer reviewed

The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination

G F Wu, A A Dandekar, L Pewe and S Perlman

Advances in experimental medicine and biology, Vol.494, pp.341-347

2001

DOI: 10.1007/978-1-4615-1325-4_51

PMID: 11774490

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Abstract

Demyelination following central nervous system (CNS) infection with the neurotropic Coronavirus, mouse hepatitis virus, strain JHM (MHV-JHM) has been shown to be dependent on the immune response of the host (Perlman, 1998). Although controversial, both CD4 and CD8 T cells are thought to contribute to demyelination (Perlman, 1998). However, the mechanisms by which each T cell subset contributes to demyelination remains unknown. To address this issue, the following questions were raised. First, what is the magnitude of the T cell response during immune-mediated demyelination? Second, what is the timing of the immune response leading to demyelination? Third, what are the roles of CD4 and CD8 T cells — in particular virus-specific T cells — during MHV-JHM-induced demyelination? In order to address these questions, a previously described adoptive transfer system (Wu and Perlman, 1999) was utilized to measure the quantity of virus-specific T cells during the process of immune-mediated demyelination. Furthermore, the individual contributions of CD4 or CD8 T cells to MHV-JHM-induced demyelinating disease were determined by depletion studies.

Demyelinating Diseases - physiopathology

Demyelinating Diseases - virology

Adoptive Transfer

Murine hepatitis virus - pathogenicity

Coronavirus Infections - immunology

CD4-Positive T-Lymphocytes - immunology

Murine hepatitis virus - immunology

Animals

CD4-Positive T-Lymphocytes - transplantation

Coronavirus Infections - virology

CD8-Positive T-Lymphocytes - virology

Demyelinating Diseases - immunology

Mice

CD8-Positive T-Lymphocytes - immunology

Details

Title: Subtitle: The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination
Creators: G F Wu - Interdisciplinary Programs in Neuroscience, University of Iowa, Iowa City, Iowa 52242, USA
A A Dandekar
L Pewe
S Perlman
Resource Type: Journal article
Publication Details: Advances in experimental medicine and biology, Vol.494, pp.341-347
DOI: 10.1007/978-1-4615-1325-4_51
PMID: 11774490
NLM abbreviation: Adv Exp Med Biol
ISSN: 0065-2598
Publisher: United States
Language: English
Date published: 2001
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777351602771

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