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The role of Sox genes in lung morphogenesis and cancer
Journal article   Open access   Peer reviewed

The role of Sox genes in lung morphogenesis and cancer

Yongzhao Zhu, Yong Li, Jun Wei Jun Wei and Xiaoming Liu
International journal of molecular sciences, Vol.13(12), pp.15767-15783
11/26/2012
DOI: 10.3390/ijms131215767
PMCID: PMC3546660
PMID: 23443092
url
https://doi.org/10.3390/ijms131215767View
Published (Version of record) Open Access

Abstract

The human lung consists of multiple cell types derived from early embryonic compartments. The morphogenesis of the lung, as well as the injury repair of the adult lung, is tightly controlled by a network of signaling pathways with key transcriptional factors. Lung cancer is the third most cancer-related death in the world, which may be developed due to the failure of regulating the signaling pathways. Sox (sex-determining region Y (Sry) box-containing) family transcriptional factors have emerged as potent modulators in embryonic development, stem cells maintenance, tissue homeostasis, and cancerogenesis in multiple processes. Recent studies demonstrated that the members of the Sox gene family played important roles in the development and maintenance of lung and development of lung cancer. In this context, we summarize our current understanding of the role of Sox family transcriptional factors in the morphogenesis of lung, their oncogenic potential in lung cancer, and their potential impact in the diagnosis, prognosis, and targeted therapy of lung cancer.
 Adult Humans Lung - embryology Lung - pathology Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Neoplasm Proteins - genetics Neoplasm Proteins - metabolism SOX Transcription Factors - genetics SOX Transcription Factors - metabolism

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